                         SEQUENCE LISTING
<110>  MedImmune, Inc.

<120>  Methods of Preventing and Treating RSV Infections 
       and Related Conditions

<130>  10271-174-228

<140>  To be assinged
<141>  On even date herewith

<150>  60/623,821
<151>  2004-10-29

<150>  60/675,724
<151>  2005-04-27

<150>  60/681,233
<151>  2005-05-13

<150>  60/727,042
<151>  2005-10-14

<150>  60/727,043
<151>  2005-10-14

<160>  1496

<170>  PatentIn version 3.1

<210>  1
<211>  7
<212>  PRT
<213>  Murine

<400>  1
Thr Ser Gly Met Ser Val Gly 
1               5           

<210>  2
<211>  16
<212>  PRT
<213>  Murine

<400>  2
Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  3
<211>  10
<212>  PRT
<213>  Murine

<400>  3
Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10  

<210>  4
<211>  10
<212>  PRT
<213>  Murine

<400>  4
Lys Cys Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  5
<211>  7
<212>  PRT
<213>  Murine

<400>  5
Asp Thr Ser Lys Leu Ala Ser 
1               5           

<210>  6
<211>  9
<212>  PRT
<213>  Murine

<400>  6
Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   

<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  7
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  8
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<223>  Humanized antibody - VL Domain


<400>  8
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Lys Cys Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  9
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Ser Met Ile Thr Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  10
Thr Ala Gly Met Ser Val Gly 
1               5           

<210>  11
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  11
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  12
Ser Met Ile Thr Asn Phe Tyr Phe Asp Val 
1               5                   10  

<210>  13
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  13
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Phe Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  14
Ser Ala Ser Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  15
Asp Thr Phe Lys Leu Ala Ser 
1               5           

<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  16
Phe Gln Phe Ser Gly Tyr Pro Phe Thr 
1               5                   

<210>  17
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  17
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Pro 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  18
Thr Pro Gly Met Ser Val Gly 
1               5           

<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  19
Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser Leu Lys Asp 
1               5                   10                  15      

<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  20
Asp Met Ile Phe Asn Phe Tyr Phe Asp Val 
1               5                   10  

<210>  21
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  21
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Tyr Leu Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  22
Ser Leu Ser Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  23
Asp Thr Phe Tyr Leu Ser Ser 
1               5           

<210>  24
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  24
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Pro 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Gly Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  25
Asp Ile Trp Trp Asp Gly Lys Lys His Tyr Asn Pro Ser Leu Lys Asp 
1               5                   10                  15      

<210>  26
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  26
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Arg Gly Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  27
Asp Thr Arg Gly Leu Pro Ser 
1               5           

<210>  28
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  28
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Pro 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Gly Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  29
Asp Met Ile Phe Asn Trp Tyr Phe Asp Val 
1               5                   10  

<210>  30
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  30
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Pro Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Met Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  31
Ser Pro Ser Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  32
Asp Thr Met Arg Leu Ala Ser 
1               5           

<210>  33
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  33
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Gly Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  34
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  34
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  35
Asp Thr Phe Lys Leu Ser Ser 
1               5           

<210>  36
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  36
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Gly Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  37
Asp Ile Trp Trp Asp Gly Lys Lys Asp Tyr Asn Pro Ser Leu Lys Asp 
1               5                   10                  15      

<210>  38
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  38
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  39
Ser Ala Ser Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  40
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  40
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Gly Lys Lys Ser Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  41
Asp Ile Trp Trp Asp Gly Lys Lys Ser Tyr Asn Pro Ser Leu Lys Asp 
1               5                   10                  15      

<210>  42
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  42
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Met Tyr Gln Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  43
Asp Thr Met Tyr Gln Ser Ser 
1               5           

<210>  44
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  44
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Ser Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  45
Asp Ile Trp Trp Asp Asp Lys Lys Ser Tyr Asn Pro Ser Leu Lys Asp 
1               5                   10                  15      

<210>  46
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  46
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Leu Pro Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Met Tyr Gln Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  47
Leu Pro Ser Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  48
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  48
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  49
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  49
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Phe Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  50
Asp Thr Phe Phe Leu Asp Ser 
1               5           

<210>  51
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  51
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Ser Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  52
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  52
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Pro Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Arg Tyr Gln Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  53
Asp Thr Arg Tyr Gln Ser Ser 
1               5           

<210>  54
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  54
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  55
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  55
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  56
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  56
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  57
Asp Thr Tyr Lys Gln Thr Ser 
1               5 

<210>  58
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  58
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Arg Tyr Leu Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     
          
<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  59
Asp Thr Arg Tyr Leu Ser Ser 
1               5                     

<210>  60
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  60
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Phe Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  61
Phe Gln Gly Ser Phe Tyr Pro Phe Thr 
1               5                   

<210>  62
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  62
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 

            100                 105     

<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  63
Asp Thr Phe Lys Leu Thr Ser 
1               5           

<210>  64
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  64
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  65
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  65
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  66
Asp Thr Phe Arg Leu Ala Ser 
1               5           

<210>  67
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  67
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  68
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  68
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Pro Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Tyr Arg His Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  69

<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  69
Asp Thr Tyr Arg His Ser Ser 
1               5           

<210>  70
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  70
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Tyr Lys Gln Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  71
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  71
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Phe His Arg Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  72
Ser Leu Ser Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  73
Asp Thr Phe Phe His Arg Ser 
1               5           

<210>  74
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  74
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Leu Leu Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  75
Asp Thr Leu Leu Leu Asp Ser 
1               5           

<210>  76
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  76
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Ser Phe Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210>  77
<211>  7
<212>  PRT

<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  77
Asp Thr Ser Phe Leu Asp Ser 
1               5           

<210>  78
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  78
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Thr Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  79
Asp Met Ile Thr Asn Phe Tyr Phe Asp Val 
1               5                   10  

<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  80
Lys Cys Gln Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  81
Asp Thr Ser Tyr Leu Ala Ser 
1               5           

<210>  82
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  82
Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  83
Asp Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10  

<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  84
Lys Cys Gln Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  85
Asp Thr Ser Tyr Leu Ser Ser 
1               5           

<210>  86
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  86
Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Asp 
1               5                   10                  15      

<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  87
Lys Cys Gln Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  88
Asp Thr Lys Lys Leu Ser Ser 
1               5           

<210>  89
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  89
Lys Leu Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  90
Asp Thr Phe Tyr Leu Ser Ser 
1               5           

<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  91
Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  92
Lys Leu Gln Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  93
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  93
Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  94
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  94
Ser Met Ile Phe Asn Trp Tyr Phe Asp Val 
1               5                   10  

<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  95
Lys Leu Gln Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  96
Asp Thr Phe Lys Leu Ser Ser 
1               5           

<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  97
Ser Met Ile Phe Asn Phe Tyr Phe Asp Val 
1               5                   10  

<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  98
Lys Leu Gln Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  99
Asp Thr Phe Tyr Leu Ala Ser 
1               5           

<210>  100
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  100
Asp Ile Trp Trp Asp Gly Lys Lys Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  101
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  101
Lys Leu Ser Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions


<400>  102
Asp Thr Ser Lys Leu Pro Ser 
1               5           

<210>  103
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  103
Asp Ile Trp Trp Asp Gly Lys Lys Asp Tyr Asn Pro Ser Leu Lys Asp 
1               5                   10                  15      

<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  104
Lys Leu Ser Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  105
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  105

Asp Thr Ser Gly Leu Ala Ser 
1               5           

<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  106
Asp Ile Trp Trp Asp Gly Lys Lys His Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  107
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  107
Lys Leu Ser Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  108
Asp Thr Ser Gly Leu Pro Ser 
1               5           

<210>  109
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  109
Asp Ile Trp Trp Asp Asp Lys Lys Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  110
Lys Leu Ser Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  111
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  111
Asp Ile Trp Trp Asp Asp Lys Lys Ser Tyr Asn Pro Ser Leu Lys Asp 
1               5                   10                  15      

<210>  112
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  112
Lys Cys Ser Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  113
Asp Thr Arg Lys Leu Ala Ser 
1               5           

<210>  114
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  114
Asp Ile Trp Trp Asp Gly Lys Lys Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  115
Lys Cys Ser Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  116
Asp Thr Arg Gly Leu Ala Ser 
1               5           

<210>  117
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  117
Lys Cys Ser Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  118
Asp Thr Arg Lys Leu Pro Ser 
1               5           

<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  119
Lys Cys Ser Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  120
Ser Leu Ser Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  121
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  121
Asp Thr Met Lys Leu Ala Ser 
1               5           

<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  122
Ser Leu Ser Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  123
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  123
Asp Thr Ser Arg Leu Ala Ser 
1               5           

<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  124
Asp Thr Ser Leu Leu Ala Ser 
1               5           

<210>  125
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  125
Ser Leu Ser Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  126
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  126
Asp Thr Ser Leu Leu Asp Ser 
1               5           

<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  127
Ser Cys Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  128
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  128
Asp Thr Ser Lys Leu Asp Ser 
1               5           

<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  129
Ser Cys Gln Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  130
Ser Cys Gln Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  131
Asp Thr Leu Lys Leu Asp Ser 
1               5           

<210>  132
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  132
Ser Cys Gln Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  133
Asp Thr Leu Leu Leu Ala Ser 
1               5           

<210>  134
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  134
Ser Leu Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  135
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  135
Asp Thr Leu Lys Leu Ala Ser 
1               5           

<210>  136
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  136
Ser Leu Gln Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  137
Asp Thr Ser Lys Leu Ser Ser 
1               5           

<210>  138
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  138
Ser Leu Gln Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  139
Asp Thr Ser Lys Gln Ala Ser 
1               5           

<210>  140
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  140
Ser Leu Gln Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  141
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  141
Asp Thr Ser Lys Gln Ser Ser 
1               5           

<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  142
Ser Cys Ser Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  143
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  143
Asp Thr Ser Tyr Leu Ala Ser 
1               5           

<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  144
Ser Cys Ser Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  145
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  145
Asp Thr Ser Tyr Leu Ser Ser 
1               5           

<210>  146
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  146
Ser Cys Ser Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  147
Asp Thr Ser Tyr Gln Ala Ser 
1               5           

<210>  148
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  148
Ser Cys Ser Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  149
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  149
Asp Thr Ser Tyr Gln Ser Ser 
1               5           

<210>  150
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  150
Lys Pro Ser Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  151
Asp Thr Met Tyr Gln Ala Ser 
1               5           

<210>  152
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  152
Lys Pro Ser Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  153
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  153
Lys Pro Ser Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  154
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  154
Asp Thr Met Lys Gln Ala Ser 
1               5           

<210>  155
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  155
Lys Pro Ser Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  156
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  156
Asp Thr Met Lys Gln Ser Ser 
1               5           

<210>  157
<211>  10

<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  157
Lys Pro Gln Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  158
Asp Thr Met Tyr Leu Ala Ser 
1               5           

<210>  159
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  159
Lys Pro Gln Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  160
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  160
Asp Thr Met Tyr Leu Ser Ser 
1               5           

<210>  161
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  161
Lys Pro Gln Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  162
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  162
Asp Thr Met Lys Leu Ala Ser 
1               5           

<210>  163
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  163
Lys Pro Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  164
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  164
Asp Thr Met Lys Leu Ser Ser 
1               5           

<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  165
Asp Thr Ser Lys Leu Ser Ser 
1               5           

<210>  166
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  166
Ser Pro Ser Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  167
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  167
Asp Thr Arg Tyr Gln Ala Ser 
1               5           

<210>  168
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  168
Ser Pro Ser Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  169
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  169
Ser Pro Ser Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  170
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  170
Asp Thr Arg Tyr Gln Ala Ser 
1               5           

<210>  171
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  171
Ser Pro Gln Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  172
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  172
Asp Thr Arg Lys Gln Ser Ser 
1               5           

<210>  173
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  173
Ser Pro Gln Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  174
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  174
Asp Thr Arg Lys Leu Ala Ser 
1               5           


<210>  175
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  175
Asp Thr Arg Lys Leu Ser Ser 
1               5           

<210>  176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  176
Ser Pro Gln Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  177
Ser Pro Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  178
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  178

Asp Thr Arg Tyr Leu Ala Ser 
1               5           

<210>  179
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  179
Lys Ala Gln Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  180
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  180
Lys Ala Gln Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  181
Lys Ala Gln Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  182
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  182
Lys Ala Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  183
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  183
Lys Ala Ser Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  184
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  184
Lys Ala Ser Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  185
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  185
Lys Ala Ser Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  186
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  186
Lys Ala Ser Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  187
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  187
Ser Ala Ser Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  188
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  188

Ser Ala Ser Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  189
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  189
Ser Ala Gln Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  190
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  190
Ser Ala Gln Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  191
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  191
Ser Ala Gln Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  192
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  192
Leu Pro Ser Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  193
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions


<400>  193
Leu Pro Ser Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  194
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  194
Leu Pro Ser Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  195
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  195
Leu Cys Ser Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  196
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  196
Leu Cys Ser Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  197
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  197
Leu Cys Ser Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  198
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  198
Leu Cys Ser Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  199
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  199
Leu Pro Gln Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  200
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  200
Leu Pro Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  201
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  201
Leu Pro Gln Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  202
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  202
Leu Pro Gln Leu Arg Val Gly Tyr Met His 
1               5                   10  


<210>  203
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  203
Leu Cys Gln Ser Arg Val Gly Tyr Met His 
1               5                   10  

<210>  204
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  204
Leu Cys Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  205
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  205
Leu Cys Gln Ser Ser Val Gly Tyr Met His 
1               5                   10  

<210>  206
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  206
Leu Cys Gln Leu Arg Val Gly Tyr Met His 
1               5                   10  

<210>  207
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  207
Ser Ala Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  

<210>  208
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  208
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  209
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  209
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Lys Cys Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  210
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  210
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Ser Met Ile Thr Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  211
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  211
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Phe Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  212
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  212
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Pro 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  213
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  213
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Tyr Leu Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  214
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  214
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Pro 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Gly Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  215
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  215
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Arg Gly Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  216
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  216
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Pro 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Gly Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  217
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  217
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Pro Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Met Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  218
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  218
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Gly Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  219
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  219
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  220
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  220
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Gly Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  221
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  221
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  222
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  222
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Gly Lys Lys Ser Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 

<210>  223
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  223
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Met Tyr Gln Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  224
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  224
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Ser Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 

        435                 440                 445             

Gly Lys 
    450 

<210>  225
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  225
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Leu Pro Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Met Tyr Gln Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  226
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  226
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  227
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  227
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Phe Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  228
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  228
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Ser Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  229
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  229
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Pro Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Arg Tyr Gln Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  230
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  230
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr
                85                  90                  95      

Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Gln
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
        435                 440                 445             


Gly Lys 
    450     

<210>  231
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  231
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  232
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  232
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  233
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  233
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  234
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  234
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  235
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  235
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Tyr Lys Gln Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  236
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  236
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  237
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  237
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Arg Tyr Leu Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  238
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  238
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Thr Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  239
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  239
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  240
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  240
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  



Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Ser Met Ile Thr Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  241
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  241
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Phe Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  242
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  242
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Thr Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  243
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  243
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  244
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  244
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Thr Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  245
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  245
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  246
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  246
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Thr Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  247
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  247
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  248
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  248
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 

        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  249
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  249
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Pro Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Tyr Arg His Ser Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210                 

<210>  250
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  250
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Gly Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  251
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  251
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Phe His Arg Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  252
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  252
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  253
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  253
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Leu Leu Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  254
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  254
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  255
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  255
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  256
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  256
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  257
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  257
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Ser Phe Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             


<210>  258
<211>  26
<212>  DNA
<213>  Artificial 

<220>
<223> Description of Artificial Sequence: Primer

<400>  258
agtgtcttaa ccagcaaagt gttaga                                       26

<210>  259
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: Primer

<400>  259
tcattgactt gagatattga tgcatc                                       26

<210>  260
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223> Linker for constructing humanized antibodies

<400>  260
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  261
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223> Linker for constructing humanized antibodies

<400>  261
Glu Ser Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  262
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223> Linker for constructing humanized antibodies

<400>  262
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  

<210>  263
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223> Linker for constructing humanized antibodies

<400>  263
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gln 
1               5                   10                  15  

<210>  264
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223> Linker for constructing humanized antibodies

<400>  264
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  

<210>  265
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223> Linker for constructing humanized antibodies

<400>  265
Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  

<210>  266
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223> Linker for constructing humanized antibodies

<400>  266
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      

Leu Asp 
        

<210>  267
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223> Linker for constructing humanized antibodies

<400>  267
Glu Ser Gly Ser Val Ser Ser Glu Glu Leu Ala Phe Arg Ser Leu Asp 
1               5                   10                  15      

<210>  268
<211>  4
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  268
Lys Asp Glu Leu 
1               

<210>  269
<211>  4
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  269
Asp Asp Glu Leu 
1               

<210>  270
<211>  4
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  270
Asp Glu Glu Leu 
1               

<210>  271
<211>  4
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  271
Gln Glu Asp Leu 
1               

<210>  272
<211>  4
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  272
Arg Asp Glu Leu 
1               

<210>  273
<211>  7
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  273
Pro Lys Lys Lys Arg Lys Val 
1               5           

<210>  274
<211>  7
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  274
Pro Gln Lys Lys Ile Lys Ser 
1               5           

<210>  275
<211>  5
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  275
Gln Pro Lys Lys Pro 
1               5   

<210>  276
<211>  4
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  276
Arg Lys Lys Arg 
1               

<210>  277
<211>  5
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  277
Lys Lys Lys Arg Lys 
1               5   

<210>  278
<211>  12
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  278
Arg Lys Lys Arg Arg Gln Arg Arg Arg Ala His Gln 
1               5                   10          

<210>  279
<211>  16
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  279
Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg Gln Arg 
1               5                   10                  15      

<210>  280
<211>  19
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  280
Met Pro Leu Thr Arg Arg Arg Pro Ala Ala Ser Gln Ala Leu Ala Pro 
1               5                   10                  15      

Pro Thr Pro 
            

<210>  281
<211>  15
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  281
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro 
1               5                   10                  15  

<210>  282
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<220>
<221>  misc_feature
<222>  7, 8, 32,
<223>  Xaa can be any naturally occurring amino acid

<400>  282
Met Leu Phe Asn Leu Arg Xaa Xaa Leu Asn Asn Ala Ala Phe Arg His 
1               5                   10                  15      

Gly His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Xaa 
            20                  25                  30          

<210>  283
<211>  3
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  283
Ala Lys Leu 
1           

<210>  284
<211>  6
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  284
Ser Asp Tyr Gln Arg Leu 
1               5       

<210>  285
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  285
Gly Cys Val Cys Ser Ser Asn Pro 
1               5               

<210>  286
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  286
Gly Gln Thr Val Thr Thr Pro Leu 
1               5               

<210>  287
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  287
Gly Gln Glu Leu Ser Gln His Glu 
1               5               

<210>  288
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  288
Gly Asn Ser Pro Ser Tyr Asn Pro 
1               5               

<210>  289
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  289
Gly Val Ser Gly Ser Lys Gly Gln 
1               5               

<210>  290
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  290
Gly Gln Thr Ile Thr Thr Pro Leu 
1               5               

<210>  291
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  291
Gly Gln Thr Leu Thr Thr Pro Leu 
1               5               

<210>  292
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  292
Gly Gln Ile Phe Ser Arg Ser Ala 
1               5               


<210>  293
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  293
Gly Gln Ile His Gly Leu Ser Pro 
1               5               

<210>  294
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  294
Gly Ala Arg Ala Ser Val Leu Ser 
1               5               


<210>  295
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  295
Gly Cys Thr Leu Ser Ala Glu Glu 
1               5               

<210>  296
<211>  16
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  296
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      

<210>  297
<211>  12
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  297
Ala Ala Val Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10          

<210>  298
<211>  15
<212>  PRT
<213>  Homo sapiens

<220>
<223> intrabody

<400>  298
Val Thr Val Leu Ala Leu Gly Ala Leu Ala Gly Val Gly Val Gly 
1               5                   10                  15  

<210> 299
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Primer

<400> 299
ccagcagtac cacttccttg ccctgcgccg                                  30

<210> 300
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Primer

<400> 300
gccgcgtccc gttccttcac catgacgacc                                  30

<210> 301
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Primer

<400> 301
ccagcagtac cgcttccttg ccctgcggcc g                                31

<210> 302
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Primer

<400> 302
gccgcgtccc gttccttcac catgacgacc                                  30

<210>  303
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  303
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Gly Asp Lys Gly His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450
 
<210>  304
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  304
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Gly Asp Lys Gly His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser
        115                 120

<210>  305
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  305
Asp Ile Trp Trp Gly Asp Lys Gly His Tyr Asn Pro Ser Leu Lys Asp 
1               5                   10                  15      

<210>  306
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  306
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Tyr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  307
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  307
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Tyr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105

<210>  308
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  308
Asp Thr Phe Tyr Leu His Ser
1               5    

<210>  309
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  309
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Ser Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  310
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  310
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Ser Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser  
        115                 120             

<210>  311
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  311
Asp Met Ile Thr Asn Trp Tyr Phe Asp Val
1               5                   10   

<210>  312
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  312
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Leu Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Tyr Tyr Gln Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  313
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  313
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Leu Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Tyr Tyr Gln Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105
      
<210>  314
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  314
Leu Leu Ser Ser Arg Val Gly Tyr Met His
 1               5                  10  

<210>  315
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  315
Asp Thr Tyr Tyr Gln Thr Ser
1               5     

<210>  316
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  316
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  317
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  317
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser  
        115                 120            

<210>  318
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  318
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Leu Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Met Tyr Gln Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  319
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  319
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Leu Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Met Tyr Gln Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105
      
<210>  320
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  320
Leu Leu Ser Ser Arg Val Gly Tyr Met His
 1               5                  10  

<210>  321
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  321
Asp Thr Met Tyr Gln Ala Ser
1               5     

<210>  322
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  322
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450 

<210>  323
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  323
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  324
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  324
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Tyr Tyr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  325
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  325
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Tyr Tyr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105 

<210>  326
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  326
Asp Thr Tyr Tyr Leu Pro Ser
1               5         

<210>  327
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Chain

<400>  327
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             

Gly Lys 
    450
 
<210>  328
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  328
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Asp Met Ile Phe Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser
        115                 120

<210>  329
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  329
Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Asp 
1               5                   10                  15  

<210>  330
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  330
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Arg His Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  331
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  331
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Leu Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Phe Arg His Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105

<210>  332
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  332
Asp Thr Phe Arg His Thr Ser
1               5         

<210>  333
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Chain

<400>  333
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Pro Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Tyr Tyr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         

Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             

Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 

Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 

Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     

Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         

Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             

Asn Arg Gly Glu Cys 
    210             

<210>  334
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VL Domain

<400>  334
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Ser Pro Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              

Asp Thr Tyr Tyr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105

<210>  335
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  335
Ser Pro Ser Ser Ser Val Gly Tyr Met His
 1               5                  10  

<210>  336
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  336
Asp Thr Tyr Tyr Leu Ala Ser
1               5         

<210>  337
<211>  365
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human FcRn

<400>  337
Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe
1               5                   10                  15

Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr
            20                  25                  30    

His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp
        35                  40                  45        

Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu
    50                  55                  60            

Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val
65                  70                  75                  80

Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys
                85                  90                  95

Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr
            100                 105                 110   

Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val
        115                 120                 125       

Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp
    130                 135                 140           

Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile
145                 150                 155                 160

Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr
                165                 170                 175

Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg
            180                 185                 190   

Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys
        195                 200                 205       

Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe
    210                 215                 220           

Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu
225                 230                 235                 240

Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser
                245                 250                 255

Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His
            260                 265                 270   

Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val
        275                 280                 285       

Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val
    290                 295                 300           

Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu
305                 310                 315                 320

Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg
                325                 330                 335

Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp
            340                 345                 350   

Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala
        355                 360                 365

<210>  338
<211>  365
<212>  PRT
<213>  Murine

<400>  338
Met Gly Met Pro Leu Pro Trp Ala Leu Ser Leu Leu Leu Val Leu Leu
1               5                   10                  15

Pro Gln Thr Trp Gly Ser Glu Thr Arg Pro Pro Leu Met Tyr His Leu
            20                  25                  30    

Thr Ala Val Ser Asn Pro Ser Thr Gly Leu Pro Ser Phe Trp Ala Thr
        35                  40                  45        

Gly Trp Leu Gly Pro Gln Gln Tyr Leu Thr Tyr Asn Ser Leu Arg Gln
    50                  55                  60            

Glu Ala Asp Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val Ser Trp
65                  70                  75                  80

Tyr Trp Glu Lys Glu Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu Phe
                85                  90                  95

Leu Glu Ala Leu Lys Thr Leu Glu Lys Ile Leu Asn Gly Thr Tyr Thr
            100                 105                 110   

Leu Gln Gly Leu Leu Gly Cys Glu Leu Ala Ser Asp Asn Ser Ser Val
        115                 120                 125       

Pro Thr Ala Val Phe Ala Leu Asn Gly Glu Glu Phe Met Lys Phe Asn
    130                 135                 140           

Pro Arg Ile Gly Asn Trp Thr Gly Glu Trp Pro Glu Thr Glu Ile Val
145                 150                 155                 160

Ala Asn Leu Trp Met Lys Gln Pro Asp Ala Ala Arg Lys Glu Ser Glu
                165                 170                 175

Phe Leu Leu Asn Ser Cys Pro Glu Arg Leu Leu Gly His Leu Glu Arg
            180                 185                 190   

Gly Arg Arg Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys
        195                 200                 205       

Ala Arg Pro Gly Asn Ser Gly Ser Ser Val Leu Thr Cys Ala Ala Phe
    210                 215                 220           

Ser Phe Tyr Pro Pro Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly Leu
225                 230                 235                 240

Ala Ser Gly Ser Gly Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly Ser
                245                 250                 255

Phe His Ala Trp Ser Leu Leu Glu Val Lys Arg Gly Asp Glu His His
            260                 265                 270   

Tyr Gln Cys Gln Val Glu His Glu Gly Leu Ala Gln Pro Leu Thr Val
        275                 280                 285       

Asp Leu Asp Ser Ser Ala Arg Ser Ser Val Pro Val Val Gly Ile Val
    290                 295                 300           

Leu Gly Leu Leu Leu Val Val Val Ala Ile Ala Gly Gly Val Leu Leu
305                 310                 315                 320

Trp Gly Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Leu Ser Leu Ser
                325                 330                 335

Gly Asp Asp Ser Gly Asp Leu Leu Pro Gly Gly Asn Leu Pro Pro Glu
            340                 345                 350   

Ala Glu Pro Gln Gly Ala Asn Ala Phe Pro Ala Thr Ser
        355                 360                 365

<210>  339
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  339
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110  

<210>  340
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  340
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
1               5                   10                  15

Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30    

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45        

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60            

Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105       

<210>  341
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  341
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
1               5                   10                  15

<210>  342
<211>  232
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human hinge Fc region

<400>  342
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1               5                   10                  15

Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30    

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45        

Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60            

Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80

Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95

Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110   

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125       

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
    130                 135                 140           

Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160

Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175

Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190   

Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205       

Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220           

Ser Leu Ser Leu Ser Pro Gly Lys
225                 230   

<210>  343
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody - VH Domain

<400>  343
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      

Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          

Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              

Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  

Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  344
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  344
Val Leu His Gln Asp Trp Leu
1               5     

<210>  345
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  345
Leu Met Ile Ser Arg Thr
1               5 

<210>  346
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  346
Met His Glu Ala Leu His Asn His Tyr
1               5             

<210>  347
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400>  347
Gly Gln Pro Glu Asn
1               5

<210>  348
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  348
Leu Tyr Ile Thr Arg Glu
1               5 

<210>  349
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  349
Leu Tyr Ile Ser Arg Thr
1               5 

<210>  350
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  350
Leu Tyr Ile Ser Arg Ser
1               5 

<210>  351
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  351
Leu Tyr Ile Ser Arg Arg
1               5 

<210>  352
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  352
Leu Tyr Ile Ser Arg Gln
1               5 

<210>  353
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  353
Leu Trp Ile Ser Arg Thr
1               5 

<210>  354
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  354
Leu Tyr Ile Ser Leu Gln
1               5 

<210>  355
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  355
Leu Phe Ile Ser Arg Asp
1               5 

<210>  356
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  356
Leu Phe Ile Ser Arg Thr
1               5 

<210>  357
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  357
Leu Phe Ile Ser Arg Arg
1               5 

<210>  358
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  358
Leu Phe Ile Thr Gly Ala
1               5 

<210>  359
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  359
Leu Ser Ile Ser Arg Glu
1               5 

<210>  360
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  360
Arg Thr Ile Ser Ile Ser
1               5 

<210>  361
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  361
Thr Pro His Ser Asp Trp Leu
1               5     

<210>  362
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  362
Ile Pro His Glu Asp Trp Leu
1               5     

<210>  363
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  363
Arg Thr Arg Glu Pro
1               5

<210>  364
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  364
Asp Pro Pro Glu Ser
1               5

<210>  365
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  365
Ser Asp Pro Glu Pro
1               5

<210>  366
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  366
Thr Ser His Glu Asn
1               5

<210>  367
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  367
Ser Lys Ser Glu Asn
1               5

<210>  368
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  368
His Arg Ser Glu Asn
1               5

<210>  369
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  369
Lys Ile Arg Glu Asn
1               5

<210>  370
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  370
Gly Ile Thr Glu Ser
1               5

<210>  371
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  371
Ser Met Ala Glu Pro
1               5

<210>  372
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  372
Met His Glu Ala Leu Arg Tyr His His
1               5             

<210>  373
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  373
Met His Glu Ala Leu His Phe His His
1               5             

<210>  374
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  374
Met His Glu Ala Leu Lys Phe His His
1               5             

<210>  375
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  375
Met His Glu Ala Leu Ser Tyr His Arg
1               5             

<210>  376
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  376
Thr His Glu Ala Leu His Tyr His Thr
1               5  

<210>  377
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220> 
<223> Mutants isolated from Library by panning

<400>  377
Met His Glu Ala Leu His Tyr His Tyr
1               5  

<210> 378
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Degenerate oligoes used to combine with 
      TAAssDNA template to make Library 1

<220> 
<221> misc_feature   
<222> (1)...(54)
<223> N = A, C, G, or T;  S = G or C
      
<400> 378
catgtgacct caggsnnsnn snngatsnns nnggtgtcct tgggttttgg gggg       54

<210> 379
<211> 53
<212> DNA
<213> Artificial Sequence

<220> 
<223> Degenerate oligoes used to combine with 
      TAAssDNA template to make Library 2

<220> 
<221> misc_feature   
<222> (1)...(53)
<223> N = A, C, G, or T; S = G or C
      
<400> 379
gcacttgtac tccttgccat tsnnccasnn snngtgsnns nnggtgagga cgc        53

<210> 380
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Degenerate oligoes used to combine with 
      TAAssDNA template to make Library 3

<220> 
<221> misc_feature   
<222> (1)...(38)
<223> N = A, C, G or T; S = G or C
      

<400> 380
ggtcttgtag ttsnnctcsn nsnnsnnatt gctctccc                         38

<210> 381
<211> 53
<212> DNA
<213> Artificial Sequence

<220> 
<223> Degenerate oligoes used to combine with 
      TAAssDNA template to make Library 4

<220> 
<221> misc_feature   
<222> (1)...(53)
<223> N = A, C, G or T;  S = G or C
     

<400> 381
ggctcttctg cgtsnngtgs nnsnncagag cctcatgsnn cacggagcat gag        53

<210> 382
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> site-directed mutagenesis primer

<400> 382
gcatgtgacc tcaggttccc gagtgatata gagggtgtcc ttggg                 45

<210> 383
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> site-directed mutagenesis primer

<400> 383
cccaaggaca ccctctatat cactcgggaa cctgaggtca catgc                 45

<210> 384
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 384
Asp Ile Trp Trp Asp Asp Lys Gly Asp Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 385
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 385
Asp Ile Trp Trp Asp Asp Lys Gly Asp Tyr Asn Pro Ser Leu Lys Asp
 1               5                  10                  15      


<210> 386
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 386
Asp Ile Trp Trp Asp Asp Lys Gly His Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 387
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 387
Asp Ile Trp Trp Asp Asp Lys Gly His Tyr Asn Pro Ser Leu Lys Asp
 1               5                  10                  15      


<210> 388
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 388
Asp Ile Trp Trp Asp Asp Lys Gly Ser Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 389
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 389
Asp Ile Trp Trp Asp Asp Lys Gly Ser Tyr Asn Pro Ser Leu Lys Asp
 1               5                  10                  15      


<210> 390
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 390
Asp Ile Trp Trp Asp Gly Lys Gly Asp Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 391
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 391
Asp Ile Trp Trp Asp Gly Lys Gly Asp Tyr Asn Pro Ser Leu Lys Asp
 1               5                  10                  15      


<210> 392
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 392
Asp Ile Trp Trp Asp Gly Lys Gly His Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 393
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 393
Asp Ile Trp Trp Asp Gly Lys Gly His Tyr Asn Pro Ser Leu Lys Asp
 1               5                  10                  15      


<210> 394
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 394
Asp Ile Trp Trp Asp Gly Lys Gly Ser Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 395
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 395
Asp Ile Trp Trp Asp Gly Lys Gly Ser Tyr Asn Pro Ser Leu Lys Asp
 1               5                  10                  15      


<210> 396
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 396
Lys Cys Gln Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 397
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 397
Lys Cys Gln Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 398
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 398
Lys Cys Gln Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 399
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 399
Lys Cys Gln Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 400
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 400
Lys Cys Gln Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 401
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 401
Lys Cys Ser Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 402
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 402
Lys Cys Ser Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 403
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 403
Lys Cys Ser Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 404
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 404
Lys Cys Ser Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 405
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 405
Lys Cys Ser Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 406
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 406
Lys Ala Gln Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 407
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 407
Lys Ala Gln Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 408
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 408
Lys Ala Gln Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 409
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 409
Lys Ala Gln Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 410
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 410
Lys Ala Gln Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 411
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 411
Lys Ala Ser Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 412
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 412
Lys Ala Ser Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 413
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 413
Lys Ala Ser Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 414
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 414
Lys Ala Ser Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 415
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 415
Lys Ala Ser Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 416
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 416
Lys Leu Gln Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 417
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 417
Lys Leu Gln Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 418
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 418
Lys Leu Gln Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 419
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 419
Lys Leu Gln Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 420
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 420
Lys Leu Gln Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 421
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 421
Lys Leu Ser Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 422
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 422
Lys Leu Ser Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 423
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 423
Lys Leu Ser Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 424
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 424
Lys Leu Ser Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 425
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 425
Lys Leu Ser Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 426
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 426
Lys Pro Gln Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 427
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 427
Lys Pro Gln Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 428
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 428
Lys Pro Gln Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 429
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 429
Lys Pro Gln Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 430
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 430
Lys Pro Gln Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 431
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 431
Lys Pro Ser Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 432
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 432
Lys Pro Ser Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 433
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 433
Lys Pro Ser Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 434
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 434
Lys Pro Ser Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 435
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 435
Lys Pro Ser Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 436
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 436
Ser Cys Gln Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 437
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 437
Ser Cys Gln Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 438
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 438
Ser Cys Gln Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 439
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 439
Ser Cys Gln Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 440
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 440
Ser Cys Gln Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 441
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 441
Ser Cys Ser Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 442
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 442
Ser Cys Ser Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 443
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 443
Ser Cys Ser Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 444
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 444
Ser Cys Ser Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 445
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 445
Ser Cys Ser Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 446
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 446
Ser Ala Gln Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 447
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 447
Ser Ala Gln Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 448
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 448
Ser Ala Gln Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 449
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 449
Ser Ala Gln Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 450
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 450
Ser Ala Gln Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 451
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 451
Ser Ala Ser Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 452
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 452
Ser Ala Ser Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 453
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 453
Ser Ala Ser Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 454
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 454
Ser Ala Ser Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 455
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 455
Ser Ala Ser Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 456
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 456
Ser Leu Gln Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 457
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 457
Ser Leu Gln Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 458
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 458
Ser Leu Gln Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 459
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 459
Ser Leu Gln Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 460
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 460
Ser Leu Gln Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 461
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 461
Ser Leu Ser Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 462
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 462
Ser Leu Ser Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 463
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 463
Ser Leu Ser Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 464
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 464
Ser Leu Ser Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 465
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 465
Ser Leu Ser Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 466
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 466
Ser Pro Gln Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 467
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 467
Ser Pro Gln Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 468
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 468
Ser Pro Gln Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 469
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 469
Ser Pro Gln Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 470
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 470
Ser Pro Gln Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 471
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 471
Ser Pro Ser Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 472
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 472
Ser Pro Ser Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 473
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 473
Ser Pro Ser Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 474
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 474
Ser Pro Ser Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 475
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 475
Ser Pro Ser Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 476
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 476
Leu Cys Gln Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 477
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 477
Leu Cys Gln Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 478
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 478
Leu Cys Gln Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 479
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 479
Leu Cys Gln Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 480
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 480
Leu Cys Gln Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 481
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 481
Leu Cys Ser Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 482
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 482
Leu Cys Ser Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 483
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 483
Leu Cys Ser Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 484
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 484
Leu Cys Ser Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 485
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 485
Leu Cys Ser Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 486
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 486
Leu Ala Gln Leu Ser Val Gly Tyr Met His
 1               5                  10  


<210> 487
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 487
Leu Ala Gln Leu Arg Val Gly Tyr Met His
 1               5                  10  


<210> 488
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 488
Leu Ala Gln Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 489
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 489
Leu Ala Gln Ser Ser Val Gly Tyr Met His
 1               5                  10  


<210> 490
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 490
Leu Ala Gln Ser Arg Val Gly Tyr Met His
 1               5                  10  


<210> 491
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 491
Leu Ala Gln Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 492
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 492
Leu Ala Gln Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 493
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 493
Leu Ala Gln Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 494
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 494
Leu Ala Gln Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 495
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 495
Leu Ala Ser Leu Ser Val Gly Tyr Met His
 1               5                  10  


<210> 496
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 496
Leu Ala Ser Leu Arg Val Gly Tyr Met His
 1               5                  10  


<210> 497
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 497
Leu Ala Ser Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 498
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 498
Leu Ala Ser Ser Ser Val Gly Tyr Met His
 1               5                  10  


<210> 499
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 499
Leu Ala Ser Ser Arg Val Gly Tyr Met His
 1               5                  10  


<210> 500
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 500
Leu Ala Ser Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 501
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 501
Leu Ala Ser Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 502
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 502
Leu Ala Ser Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 503
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 503
Leu Ala Ser Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 504
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 504
Leu Leu Gln Leu Ser Val Gly Tyr Met His
 1               5                  10  


<210> 505
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 505
Leu Leu Gln Leu Arg Val Gly Tyr Met His
 1               5                  10  


<210> 506
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 506
Leu Leu Gln Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 507
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 507
Leu Leu Gln Ser Ser Val Gly Tyr Met His
 1               5                  10  


<210> 508
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 508
Leu Leu Gln Ser Arg Val Gly Tyr Met His
 1               5                  10  


<210> 509
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 509
Leu Leu Gln Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 510
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 510
Leu Leu Gln Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 511
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 511
Leu Leu Gln Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 512
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 512
Leu Leu Gln Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 513
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 513
Leu Leu Ser Leu Ser Val Gly Tyr Met His
 1               5                  10  


<210> 514
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 514
Leu Leu Ser Leu Arg Val Gly Tyr Met His
 1               5                  10  


<210> 515
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 515
Leu Leu Ser Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 516
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 516
Leu Leu Ser Ser Ser Val Gly Tyr Met His
 1               5                  10  


<210> 517
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 517
Leu Leu Ser Ser Arg Val Gly Tyr Met His
 1               5                  10  


<210> 518
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 518
Leu Leu Ser Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 519
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 519
Leu Leu Ser Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 520
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 520
Leu Leu Ser Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 521
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 521
Leu Leu Ser Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 522
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 522
Leu Pro Gln Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 523
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 523
Leu Pro Gln Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 524
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 524
Leu Pro Gln Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 525
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 525
Leu Pro Gln Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 526
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 526
Leu Pro Gln Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 527
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 527
Leu Pro Ser Leu Phe Val Gly Tyr Met His
 1               5                  10  


<210> 528
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 528
Leu Pro Ser Ser Phe Val Gly Tyr Met His
 1               5                  10  


<210> 529
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 529
Leu Pro Ser Val Ser Val Gly Tyr Met His
 1               5                  10  


<210> 530
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 530
Leu Pro Ser Val Arg Val Gly Tyr Met His
 1               5                  10  


<210> 531
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 531
Leu Pro Ser Val Phe Val Gly Tyr Met His
 1               5                  10  


<210> 532
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 532
Asp Thr Ser Lys Leu Lys Ser
 1               5          


<210> 533
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 533
Asp Thr Ser Lys Leu Arg Ser
 1               5          


<210> 534
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 534
Asp Thr Ser Lys Leu His Ser
 1               5          


<210> 535
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 535
Asp Thr Ser Lys Leu Thr Ser
 1               5          


<210> 536
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 536
Asp Thr Ser Lys His Ala Ser
 1               5          


<210> 537
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 537
Asp Thr Ser Lys His Ser Ser
 1               5          


<210> 538
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 538
Asp Thr Ser Lys His Lys Ser
 1               5          


<210> 539
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 539
Asp Thr Ser Lys His Arg Ser
 1               5          


<210> 540
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 540
Asp Thr Ser Lys His His Ser
 1               5          


<210> 541
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 541
Asp Thr Ser Lys His Pro Ser
 1               5          


<210> 542
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 542
Asp Thr Ser Lys His Thr Ser
 1               5          


<210> 543
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 543
Asp Thr Ser Lys His Asp Ser
 1               5          


<210> 544
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 544
Asp Thr Ser Lys Gln Lys Ser
 1               5          


<210> 545
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 545
Asp Thr Ser Lys Gln Arg Ser
 1               5          


<210> 546
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 546
Asp Thr Ser Lys Gln His Ser
 1               5          


<210> 547
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 547
Asp Thr Ser Lys Gln Pro Ser
 1               5          


<210> 548
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 548
Asp Thr Ser Lys Gln Thr Ser
 1               5          


<210> 549
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 549
Asp Thr Ser Lys Gln Asp Ser
 1               5          


<210> 550
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 550
Asp Thr Ser Gly Leu Ser Ser
 1               5          


<210> 551
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 551
Asp Thr Ser Gly Leu Lys Ser
 1               5          


<210> 552
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 552
Asp Thr Ser Gly Leu Arg Ser
 1               5          


<210> 553
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 553
Asp Thr Ser Gly Leu His Ser
 1               5          


<210> 554
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 554
Asp Thr Ser Gly Leu Thr Ser
 1               5          


<210> 555
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 555
Asp Thr Ser Gly Leu Asp Ser
 1               5          


<210> 556
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 556
Asp Thr Ser Gly His Ala Ser
 1               5          


<210> 557
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 557
Asp Thr Ser Gly His Ser Ser
 1               5          


<210> 558
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 558
Asp Thr Ser Gly His Lys Ser
 1               5          


<210> 559
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 559
Asp Thr Ser Gly His Arg Ser
 1               5          


<210> 560
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 560
Asp Thr Ser Gly His His Ser
 1               5          


<210> 561
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 561
Asp Thr Ser Gly His Pro Ser
 1               5          


<210> 562
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 562
Asp Thr Ser Gly His Thr Ser
 1               5          


<210> 563
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 563
Asp Thr Ser Gly His Asp Ser
 1               5          


<210> 564
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 564
Asp Thr Ser Gly Gln Ala Ser
 1               5          


<210> 565
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 565
Asp Thr Ser Gly Gln Ser Ser
 1               5          


<210> 566
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 566
Asp Thr Ser Gly Gln Lys Ser
 1               5          


<210> 567
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 567
Asp Thr Ser Gly Gln Arg Ser
 1               5          


<210> 568
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 568
Asp Thr Ser Gly Gln His Ser
 1               5          


<210> 569
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 569
Asp Thr Ser Gly Gln Pro Ser
 1               5          


<210> 570
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 570
Asp Thr Ser Gly Gln Thr Ser
 1               5          


<210> 571
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 571
Asp Thr Ser Gly Gln Asp Ser
 1               5          


<210> 572
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 572
Asp Thr Ser Arg Leu Ser Ser
 1               5          


<210> 573
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 573
Asp Thr Ser Arg Leu Lys Ser
 1               5          


<210> 574
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 574
Asp Thr Ser Arg Leu Arg Ser
 1               5          


<210> 575
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 575
Asp Thr Ser Arg Leu His Ser
 1               5          


<210> 576
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 576
Asp Thr Ser Arg Leu Pro Ser
 1               5          


<210> 577
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 577
Asp Thr Ser Arg Leu Thr Ser
 1               5          


<210> 578
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 578
Asp Thr Ser Arg Leu Asp Ser
 1               5          


<210> 579
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 579
Asp Thr Ser Arg His Ala Ser
 1               5          


<210> 580
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 580
Asp Thr Ser Arg His Ser Ser
 1               5          


<210> 581
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 581
Asp Thr Ser Arg His Lys Ser
 1               5          


<210> 582
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 582
Asp Thr Ser Arg His Arg Ser
 1               5          


<210> 583
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 583
Asp Thr Ser Arg His His Ser
 1               5          


<210> 584
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 584
Asp Thr Ser Arg His Pro Ser
 1               5          


<210> 585
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 585
Asp Thr Ser Arg His Thr Ser
 1               5          


<210> 586
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 586
Asp Thr Ser Arg His Asp Ser
 1               5          


<210> 587
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 587
Asp Thr Ser Arg Gln Ala Ser
 1               5          


<210> 588
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 588
Asp Thr Ser Arg Gln Ser Ser
 1               5          


<210> 589
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 589
Asp Thr Ser Arg Gln Lys Ser
 1               5          


<210> 590
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 590
Asp Thr Ser Arg Gln Arg Ser
 1               5          


<210> 591
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 591
Asp Thr Ser Arg Gln His Ser
 1               5          


<210> 592
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 592
Asp Thr Ser Arg Gln Pro Ser
 1               5          


<210> 593
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 593
Asp Thr Ser Arg Gln Thr Ser
 1               5          


<210> 594
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 594
Asp Thr Ser Arg Gln Asp Ser
 1               5          


<210> 595
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 595
Asp Thr Ser Tyr Leu Lys Ser
 1               5          


<210> 596
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 596
Asp Thr Ser Tyr Leu Arg Ser
 1               5          


<210> 597
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 597
Asp Thr Ser Tyr Leu His Ser
 1               5          


<210> 598
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 598
Asp Thr Ser Tyr Leu Pro Ser
 1               5          


<210> 599
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 599
Asp Thr Ser Tyr Leu Thr Ser
 1               5          


<210> 600
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 600
Asp Thr Ser Tyr Leu Asp Ser
 1               5          


<210> 601
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 601
Asp Thr Ser Tyr His Ala Ser
 1               5          


<210> 602
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 602
Asp Thr Ser Tyr His Ser Ser
 1               5          


<210> 603
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 603
Asp Thr Ser Tyr His Lys Ser
 1               5          


<210> 604
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 604
Asp Thr Ser Tyr His Arg Ser
 1               5          


<210> 605
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 605
Asp Thr Ser Tyr His His Ser
 1               5          


<210> 606
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 606
Asp Thr Ser Tyr His Pro Ser
 1               5          


<210> 607
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 607
Asp Thr Ser Tyr His Thr Ser
 1               5          


<210> 608
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 608
Asp Thr Ser Tyr His Asp Ser
 1               5          


<210> 609
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 609
Asp Thr Ser Tyr Gln Lys Ser
 1               5          


<210> 610
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 610
Asp Thr Ser Tyr Gln Arg Ser
 1               5          


<210> 611
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 611
Asp Thr Ser Tyr Gln His Ser
 1               5          


<210> 612
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 612
Asp Thr Ser Tyr Gln Pro Ser
 1               5          


<210> 613
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 613
Asp Thr Ser Tyr Gln Thr Ser
 1               5          


<210> 614
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 614
Asp Thr Ser Tyr Gln Asp Ser
 1               5          


<210> 615
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 615
Asp Thr Ser Phe Leu Ala Ser
 1               5          


<210> 616
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 616
Asp Thr Ser Phe Leu Ser Ser
 1               5          


<210> 617
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 617
Asp Thr Ser Phe Leu Lys Ser
 1               5          


<210> 618
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 618
Asp Thr Ser Phe Leu Arg Ser
 1               5          


<210> 619
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 619
Asp Thr Ser Phe Leu His Ser
 1               5          


<210> 620
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 620
Asp Thr Ser Phe Leu Pro Ser
 1               5          


<210> 621
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 621
Asp Thr Ser Phe Leu Thr Ser
 1               5          


<210> 622
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 622
Asp Thr Ser Phe His Ala Ser
 1               5          


<210> 623
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 623
Asp Thr Ser Phe His Ser Ser
 1               5          


<210> 624
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 624
Asp Thr Ser Phe His Lys Ser
 1               5          


<210> 625
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 625
Asp Thr Ser Phe His Arg Ser
 1               5          


<210> 626
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 626
Asp Thr Ser Phe His His Ser
 1               5          


<210> 627
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 627
Asp Thr Ser Phe His Pro Ser
 1               5          


<210> 628
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 628
Asp Thr Ser Phe His Thr Ser
 1               5          


<210> 629
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 629
Asp Thr Ser Phe His Asp Ser
 1               5          


<210> 630
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 630
Asp Thr Ser Phe Gln Ala Ser
 1               5          


<210> 631
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 631
Asp Thr Ser Phe Gln Ser Ser
 1               5          


<210> 632
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 632
Asp Thr Ser Phe Gln Lys Ser
 1               5          


<210> 633
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 633
Asp Thr Ser Phe Gln Arg Ser
 1               5          


<210> 634
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 634
Asp Thr Ser Phe Gln His Ser
 1               5          


<210> 635
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 635
Asp Thr Ser Phe Gln Pro Ser
 1               5          


<210> 636
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 636
Asp Thr Ser Phe Gln Thr Ser
 1               5          


<210> 637
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 637
Asp Thr Ser Phe Gln Asp Ser
 1               5          


<210> 638
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 638
Asp Thr Ser Leu Leu Ser Ser
 1               5          


<210> 639
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 639
Asp Thr Ser Leu Leu Lys Ser
 1               5          


<210> 640
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 640
Asp Thr Ser Leu Leu Arg Ser
 1               5          


<210> 641
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 641
Asp Thr Ser Leu Leu His Ser
 1               5          


<210> 642
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 642
Asp Thr Ser Leu Leu Pro Ser
 1               5          


<210> 643
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 643
Asp Thr Ser Leu Leu Thr Ser
 1               5          


<210> 644
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 644
Asp Thr Ser Leu His Ala Ser
 1               5          


<210> 645
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 645
Asp Thr Ser Leu His Ser Ser
 1               5          


<210> 646
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 646
Asp Thr Ser Leu His Lys Ser
 1               5          


<210> 647
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 647
Asp Thr Ser Leu His Arg Ser
 1               5          


<210> 648
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 648
Asp Thr Ser Leu His His Ser
 1               5          


<210> 649
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 649
Asp Thr Ser Leu His Pro Ser
 1               5          


<210> 650
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 650
Asp Thr Ser Leu His Thr Ser
 1               5          


<210> 651
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 651
Asp Thr Ser Leu His Asp Ser
 1               5          


<210> 652
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 652
Asp Thr Ser Leu Gln Ala Ser
 1               5          


<210> 653
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 653
Asp Thr Ser Leu Gln Ser Ser
 1               5          


<210> 654
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 654
Asp Thr Ser Leu Gln Lys Ser
 1               5          


<210> 655
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 655
Asp Thr Ser Leu Gln Arg Ser
 1               5          


<210> 656
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 656
Asp Thr Ser Leu Gln His Ser
 1               5          


<210> 657
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 657
Asp Thr Ser Leu Gln Pro Ser
 1               5          


<210> 658
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 658
Asp Thr Ser Leu Gln Thr Ser
 1               5          


<210> 659
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 659
Asp Thr Ser Leu Gln Asp Ser
 1               5          


<210> 660
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 660
Asp Thr Phe Lys Leu Lys Ser
 1               5          


<210> 661
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 661
Asp Thr Phe Lys Leu Arg Ser
 1               5          


<210> 662
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 662
Asp Thr Phe Lys Leu His Ser
 1               5          


<210> 663
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 663
Asp Thr Phe Lys Leu Pro Ser
 1               5          


<210> 664
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 664
Asp Thr Phe Lys Leu Thr Ser
 1               5          


<210> 665
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 665
Asp Thr Phe Lys Leu Asp Ser
 1               5          


<210> 666
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 666
Asp Thr Phe Lys His Ala Ser
 1               5          


<210> 667
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 667
Asp Thr Phe Lys His Ser Ser
 1               5          


<210> 668
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 668
Asp Thr Phe Lys His Lys Ser
 1               5          


<210> 669
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 669
Asp Thr Phe Lys His Arg Ser
 1               5          


<210> 670
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 670
Asp Thr Phe Lys His His Ser
 1               5          


<210> 671
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 671
Asp Thr Phe Lys His Pro Ser
 1               5          


<210> 672
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 672
Asp Thr Phe Lys His Thr Ser
 1               5          


<210> 673
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 673
Asp Thr Phe Lys His Asp Ser
 1               5          


<210> 674
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 674
Asp Thr Phe Lys Gln Ala Ser
 1               5          


<210> 675
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 675
Asp Thr Phe Lys Gln Ser Ser
 1               5          


<210> 676
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 676
Asp Thr Phe Lys Gln Lys Ser
 1               5          


<210> 677
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 677
Asp Thr Phe Lys Gln Arg Ser
 1               5          


<210> 678
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 678
Asp Thr Phe Lys Gln His Ser
 1               5          


<210> 679
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 679
Asp Thr Phe Lys Gln Pro Ser
 1               5          


<210> 680
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 680
Asp Thr Phe Lys Gln Thr Ser
 1               5          


<210> 681
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 681
Asp Thr Phe Lys Gln Asp Ser
 1               5          


<210> 682
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 682
Asp Thr Phe Gly Leu Ala Ser
 1               5          


<210> 683
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 683
Asp Thr Phe Gly Leu Ser Ser
 1               5          


<210> 684
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 684
Asp Thr Phe Gly Leu Lys Ser
 1               5          


<210> 685
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 685
Asp Thr Phe Gly Leu Arg Ser
 1               5          


<210> 686
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 686
Asp Thr Phe Gly Leu His Ser
 1               5          


<210> 687
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 687
Asp Thr Phe Gly Leu Pro Ser
 1               5          


<210> 688
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 688
Asp Thr Phe Gly Leu Thr Ser
 1               5          


<210> 689
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 689
Asp Thr Phe Gly Leu Asp Ser
 1               5          


<210> 690
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 690
Asp Thr Phe Gly His Ala Ser
 1               5          


<210> 691
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 691
Asp Thr Phe Gly His Ser Ser
 1               5          


<210> 692
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 692
Asp Thr Phe Gly His Lys Ser
 1               5          


<210> 693
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 693
Asp Thr Phe Gly His Arg Ser
 1               5          


<210> 694
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 694
Asp Thr Phe Gly His His Ser
 1               5          


<210> 695
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 695
Asp Thr Phe Gly His Pro Ser
 1               5          


<210> 696
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 696
Asp Thr Phe Gly His Thr Ser
 1               5          


<210> 697
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 697
Asp Thr Phe Gly His Asp Ser
 1               5          


<210> 698
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 698
Asp Thr Phe Gly Gln Ala Ser
 1               5          


<210> 699
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 699
Asp Thr Phe Gly Gln Ser Ser
 1               5          


<210> 700
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 700
Asp Thr Phe Gly Gln Lys Ser
 1               5          


<210> 701
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 701
Asp Thr Phe Gly Gln Arg Ser
 1               5          


<210> 702
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 702
Asp Thr Phe Gly Gln His Ser
 1               5          


<210> 703
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 703
Asp Thr Phe Gly Gln Pro Ser
 1               5          


<210> 704
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 704
Asp Thr Phe Gly Gln Thr Ser
 1               5          


<210> 705
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 705
Asp Thr Phe Gly Gln Asp Ser
 1               5          


<210> 706
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 706
Asp Thr Phe Arg Leu Ala Ser
 1               5          


<210> 707
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 707
Asp Thr Phe Arg Leu Ser Ser
 1               5          


<210> 708
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 708
Asp Thr Phe Arg Leu Lys Ser
 1               5          


<210> 709
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 709
Asp Thr Phe Arg Leu Arg Ser
 1               5          


<210> 710
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 710
Asp Thr Phe Arg Leu His Ser
 1               5          


<210> 711
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 711
Asp Thr Phe Arg Leu Pro Ser
 1               5          


<210> 712
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 712
Asp Thr Phe Arg Leu Thr Ser
 1               5          


<210> 713
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 713
Asp Thr Phe Arg Leu Asp Ser
 1               5          


<210> 714
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 714
Asp Thr Phe Arg His Ala Ser
 1               5          


<210> 715
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 715
Asp Thr Phe Arg His Ser Ser
 1               5          


<210> 716
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 716
Asp Thr Phe Arg His Lys Ser
 1               5          


<210> 717
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 717
Asp Thr Phe Arg His Arg Ser
 1               5          


<210> 718
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 718
Asp Thr Phe Arg His His Ser
 1               5          


<210> 719
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 719
Asp Thr Phe Arg His Pro Ser
 1               5          


<210> 720
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 720
Asp Thr Phe Arg His Thr Ser
 1               5          


<210> 721
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 721
Asp Thr Phe Arg His Asp Ser
 1               5          


<210> 722
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 722
Asp Thr Phe Arg Gln Ala Ser
 1               5          


<210> 723
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 723
Asp Thr Phe Arg Gln Ser Ser
 1               5          


<210> 724
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 724
Asp Thr Phe Arg Gln Lys Ser
 1               5          


<210> 725
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 725
Asp Thr Phe Arg Gln Arg Ser
 1               5          


<210> 726
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 726
Asp Thr Phe Arg Gln His Ser
 1               5          


<210> 727
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 727
Asp Thr Phe Arg Gln Pro Ser
 1               5          


<210> 728
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 728
Asp Thr Phe Arg Gln Thr Ser
 1               5          


<210> 729
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 729
Asp Thr Phe Arg Gln Asp Ser
 1               5          


<210> 730
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 730
Asp Thr Phe Tyr Leu Lys Ser
 1               5          


<210> 731
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 731
Asp Thr Phe Tyr Leu Arg Ser
 1               5          


<210> 732
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 732
Asp Thr Phe Tyr Leu His Ser
 1               5          


<210> 733
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 733
Asp Thr Phe Tyr Leu Pro Ser
 1               5          


<210> 734
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 734
Asp Thr Phe Tyr Leu Thr Ser
 1               5          


<210> 735
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 735
Asp Thr Phe Tyr Leu Asp Ser
 1               5          


<210> 736
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 736
Asp Thr Phe Tyr His Ala Ser
 1               5          


<210> 737
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 737
Asp Thr Phe Tyr His Ser Ser
 1               5          


<210> 738
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 738
Asp Thr Phe Tyr His Lys Ser
 1               5          


<210> 739
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 739
Asp Thr Phe Tyr His Arg Ser
 1               5          


<210> 740
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 740
Asp Thr Phe Tyr His His Ser
 1               5          


<210> 741
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 741
Asp Thr Phe Tyr His Pro Ser
 1               5          


<210> 742
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 742
Asp Thr Phe Tyr His Thr Ser
 1               5          


<210> 743
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 743
Asp Thr Phe Tyr His Asp Ser
 1               5          


<210> 744
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 744
Asp Thr Phe Tyr Gln Ala Ser
 1               5          


<210> 745
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 745
Asp Thr Phe Tyr Gln Ser Ser
 1               5          


<210> 746
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 746
Asp Thr Phe Tyr Gln Lys Ser
 1               5          


<210> 747
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 747
Asp Thr Phe Tyr Gln Arg Ser
 1               5          


<210> 748
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 748
Asp Thr Phe Tyr Gln His Ser
 1               5          


<210> 749
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 749
Asp Thr Phe Tyr Gln Pro Ser
 1               5          


<210> 750
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 750
Asp Thr Phe Tyr Gln Thr Ser
 1               5          


<210> 751
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 751
Asp Thr Phe Tyr Gln Asp Ser
 1               5          


<210> 752
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 752
Asp Thr Phe Phe Leu Ala Ser
 1               5          


<210> 753
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 753
Asp Thr Phe Phe Leu Ser Ser
 1               5          


<210> 754
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 754
Asp Thr Phe Phe Leu Lys Ser
 1               5          


<210> 755
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 755
Asp Thr Phe Phe Leu Arg Ser
 1               5          


<210> 756
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 756
Asp Thr Phe Phe Leu His Ser
 1               5          


<210> 757
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 757
Asp Thr Phe Phe Leu Pro Ser
 1               5          


<210> 758
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 758
Asp Thr Phe Phe Leu Thr Ser
 1               5          


<210> 759
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 759
Asp Thr Phe Phe His Ala Ser
 1               5          


<210> 760
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 760
Asp Thr Phe Phe His Ser Ser
 1               5          


<210> 761
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 761
Asp Thr Phe Phe His Lys Ser
 1               5          


<210> 762
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 762
Asp Thr Phe Phe His Arg Ser
 1               5          


<210> 763
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 763
Asp Thr Phe Phe His His Ser
 1               5          


<210> 764
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 764
Asp Thr Phe Phe His Pro Ser
 1               5          


<210> 765
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 765
Asp Thr Phe Phe His Thr Ser
 1               5          


<210> 766
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 766
Asp Thr Phe Phe His Asp Ser
 1               5          


<210> 767
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 767
Asp Thr Phe Phe Gln Ala Ser
 1               5          


<210> 768
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 768
Asp Thr Phe Phe Gln Ser Ser
 1               5          


<210> 769
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 769
Asp Thr Phe Phe Gln Lys Ser
 1               5          


<210> 770
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 770
Asp Thr Phe Phe Gln Arg Ser
 1               5          


<210> 771
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 771
Asp Thr Phe Phe Gln His Ser
 1               5          


<210> 772
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 772
Asp Thr Phe Phe Gln Pro Ser
 1               5          


<210> 773
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 773
Asp Thr Phe Phe Gln Thr Ser
 1               5          


<210> 774
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 774
Asp Thr Phe Phe Gln Asp Ser
 1               5          


<210> 775
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 775
Asp Thr Phe Leu Leu Ala Ser
 1               5          


<210> 776
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 776
Asp Thr Phe Leu Leu Ser Ser
 1               5          


<210> 777
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 777
Asp Thr Phe Leu Leu Lys Ser
 1               5          


<210> 778
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 778
Asp Thr Phe Leu Leu Arg Ser
 1               5          


<210> 779
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 779
Asp Thr Phe Leu Leu His Ser
 1               5          


<210> 780
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 780
Asp Thr Phe Leu Leu Pro Ser
 1               5          


<210> 781
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 781
Asp Thr Phe Leu Leu Thr Ser
 1               5          


<210> 782
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 782
Asp Thr Phe Leu Leu Asp Ser
 1               5          


<210> 783
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 783
Asp Thr Phe Leu His Ala Ser
 1               5          


<210> 784
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 784
Asp Thr Phe Leu His Ser Ser
 1               5          


<210> 785
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 785
Asp Thr Phe Leu His Lys Ser
 1               5          


<210> 786
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 786
Asp Thr Phe Leu His Arg Ser
 1               5          


<210> 787
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 787
Asp Thr Phe Leu His His Ser
 1               5          


<210> 788
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 788
Asp Thr Phe Leu His Pro Ser
 1               5          


<210> 789
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 789
Asp Thr Phe Leu His Thr Ser
 1               5          


<210> 790
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 790
Asp Thr Phe Leu His Asp Ser
 1               5          


<210> 791
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 791
Asp Thr Phe Leu Gln Ala Ser
 1               5          


<210> 792
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 792
Asp Thr Phe Leu Gln Ser Ser
 1               5          


<210> 793
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 793
Asp Thr Phe Leu Gln Lys Ser
 1               5          


<210> 794
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 794
Asp Thr Phe Leu Gln Arg Ser
 1               5          


<210> 795
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 795
Asp Thr Phe Leu Gln His Ser
 1               5          


<210> 796
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 796
Asp Thr Phe Leu Gln Pro Ser
 1               5          


<210> 797
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 797
Asp Thr Phe Leu Gln Thr Ser
 1               5          


<210> 798
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 798
Asp Thr Phe Leu Gln Asp Ser
 1               5          


<210> 799
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 799
Asp Thr Tyr Lys Leu Ala Ser
 1               5          


<210> 800
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 800
Asp Thr Tyr Lys Leu Ser Ser
 1               5          


<210> 801
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 801
Asp Thr Tyr Lys Leu Lys Ser
 1               5          


<210> 802
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 802
Asp Thr Tyr Lys Leu Arg Ser
 1               5          


<210> 803
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 803
Asp Thr Tyr Lys Leu His Ser
 1               5          


<210> 804
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 804
Asp Thr Tyr Lys Leu Pro Ser
 1               5          


<210> 805
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 805
Asp Thr Tyr Lys Leu Thr Ser
 1               5          


<210> 806
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 806
Asp Thr Tyr Lys Leu Asp Ser
 1               5          


<210> 807
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 807
Asp Thr Tyr Lys His Ala Ser
 1               5          


<210> 808
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 808
Asp Thr Tyr Lys His Ser Ser
 1               5          


<210> 809
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 809
Asp Thr Tyr Lys His Lys Ser
 1               5          


<210> 810
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 810
Asp Thr Tyr Lys His Arg Ser
 1               5          


<210> 811
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 811
Asp Thr Tyr Lys His His Ser
 1               5          


<210> 812
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 812
Asp Thr Tyr Lys His Pro Ser
 1               5          


<210> 813
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 813
Asp Thr Tyr Lys His Thr Ser
 1               5          


<210> 814
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 814
Asp Thr Tyr Lys His Asp Ser
 1               5          


<210> 815
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 815
Asp Thr Tyr Lys Gln Ala Ser
 1               5          


<210> 816
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 816
Asp Thr Tyr Lys Gln Ser Ser
 1               5          


<210> 817
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 817
Asp Thr Tyr Lys Gln Lys Ser
 1               5          


<210> 818
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 818
Asp Thr Tyr Lys Gln Arg Ser
 1               5          


<210> 819
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 819
Asp Thr Tyr Lys Gln His Ser
 1               5          


<210> 820
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 820
Asp Thr Tyr Lys Gln Pro Ser
 1               5          


<210> 821
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 821
Asp Thr Tyr Lys Gln Thr Ser
 1               5          


<210> 822
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 822
Asp Thr Tyr Lys Gln Asp Ser
 1               5          


<210> 823
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 823
Asp Thr Tyr Gly Leu Ala Ser
 1               5          


<210> 824
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 824
Asp Thr Tyr Gly Leu Ser Ser
 1               5          


<210> 825
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 825
Asp Thr Tyr Gly Leu Lys Ser
 1               5          


<210> 826
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 826
Asp Thr Tyr Gly Leu Arg Ser
 1               5          


<210> 827
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 827
Asp Thr Tyr Gly Leu His Ser
 1               5          


<210> 828
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 828
Asp Thr Tyr Gly Leu Pro Ser
 1               5          


<210> 829
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 829
Asp Thr Tyr Gly Leu Thr Ser
 1               5          


<210> 830
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 830
Asp Thr Tyr Gly Leu Asp Ser
 1               5          


<210> 831
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 831
Asp Thr Tyr Gly His Ala Ser
 1               5          


<210> 832
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 832
Asp Thr Tyr Gly His Ser Ser
 1               5          


<210> 833
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 833
Asp Thr Tyr Gly His Lys Ser
 1               5          


<210> 834
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 834
Asp Thr Tyr Gly His Arg Ser
 1               5          


<210> 835
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 835
Asp Thr Tyr Gly His His Ser
 1               5          


<210> 836
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 836
Asp Thr Tyr Gly His Pro Ser
 1               5          


<210> 837
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 837
Asp Thr Tyr Gly His Thr Ser
 1               5          


<210> 838
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 838
Asp Thr Tyr Gly His Asp Ser
 1               5          


<210> 839
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 839
Asp Thr Tyr Gly Gln Ala Ser
 1               5          


<210> 840
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 840
Asp Thr Tyr Gly Gln Ser Ser
 1               5          


<210> 841
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 841
Asp Thr Tyr Gly Gln Lys Ser
 1               5          


<210> 842
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 842
Asp Thr Tyr Gly Gln Arg Ser
 1               5          


<210> 843
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 843
Asp Thr Tyr Gly Gln His Ser
 1               5          


<210> 844
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 844
Asp Thr Tyr Gly Gln Pro Ser
 1               5          


<210> 845
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 845
Asp Thr Tyr Gly Gln Thr Ser
 1               5          


<210> 846
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 846
Asp Thr Tyr Gly Gln Asp Ser
 1               5          


<210> 847
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 847
Asp Thr Tyr Arg Leu Ala Ser
 1               5          


<210> 848
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 848
Asp Thr Tyr Arg Leu Ser Ser
 1               5          


<210> 849
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 849
Asp Thr Tyr Arg Leu Lys Ser
 1               5          


<210> 850
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 850
Asp Thr Tyr Arg Leu Arg Ser
 1               5          


<210> 851
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 851
Asp Thr Tyr Arg Leu His Ser
 1               5          


<210> 852
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 852
Asp Thr Tyr Arg Leu Pro Ser
 1               5          


<210> 853
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 853
Asp Thr Tyr Arg Leu Thr Ser
 1               5          


<210> 854
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 854
Asp Thr Tyr Arg Leu Asp Ser
 1               5          


<210> 855
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 855
Asp Thr Tyr Arg His Ala Ser
 1               5          


<210> 856
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 856
Asp Thr Tyr Arg His Ser Ser
 1               5          


<210> 857
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 857
Asp Thr Tyr Arg His Lys Ser
 1               5          


<210> 858
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 858
Asp Thr Tyr Arg His Arg Ser
 1               5          


<210> 859
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 859
Asp Thr Tyr Arg His His Ser
 1               5          


<210> 860
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 860
Asp Thr Tyr Arg His Pro Ser
 1               5          


<210> 861
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 861
Asp Thr Tyr Arg His Thr Ser
 1               5          


<210> 862
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 862
Asp Thr Tyr Arg His Asp Ser
 1               5          


<210> 863
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 863
Asp Thr Tyr Arg Gln Ala Ser
 1               5          


<210> 864
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 864
Asp Thr Tyr Arg Gln Ser Ser
 1               5          


<210> 865
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 865
Asp Thr Tyr Arg Gln Lys Ser
 1               5          


<210> 866
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 866
Asp Thr Tyr Arg Gln Arg Ser
 1               5          


<210> 867
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 867
Asp Thr Tyr Arg Gln His Ser
 1               5          


<210> 868
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 868
Asp Thr Tyr Arg Gln Pro Ser
 1               5          


<210> 869
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 869
Asp Thr Tyr Arg Gln Thr Ser
 1               5          


<210> 870
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 870
Asp Thr Tyr Arg Gln Asp Ser
 1               5          


<210> 871
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 871
Asp Thr Tyr Tyr Leu Ala Ser
 1               5          


<210> 872
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 872
Asp Thr Tyr Tyr Leu Ser Ser
 1               5          


<210> 873
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 873
Asp Thr Tyr Tyr Leu Lys Ser
 1               5          


<210> 874
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 874
Asp Thr Tyr Tyr Leu Arg Ser
 1               5          


<210> 875
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 875
Asp Thr Tyr Tyr Leu His Ser
 1               5          


<210> 876
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 876
Asp Thr Tyr Tyr Leu Pro Ser
 1               5          


<210> 877
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 877
Asp Thr Tyr Tyr Leu Thr Ser
 1               5          


<210> 878
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 878
Asp Thr Tyr Tyr Leu Asp Ser
 1               5          


<210> 879
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 879
Asp Thr Tyr Tyr His Ala Ser
 1               5          


<210> 880
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 880
Asp Thr Tyr Tyr His Ser Ser
 1               5          


<210> 881
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 881
Asp Thr Tyr Tyr His Lys Ser
 1               5          


<210> 882
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 882
Asp Thr Tyr Tyr His Arg Ser
 1               5          


<210> 883
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 883
Asp Thr Tyr Tyr His His Ser
 1               5          


<210> 884
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 884
Asp Thr Tyr Tyr His Pro Ser
 1               5          


<210> 885
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 885
Asp Thr Tyr Tyr His Thr Ser
 1               5          


<210> 886
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 886
Asp Thr Tyr Tyr His Asp Ser
 1               5          


<210> 887
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 887
Asp Thr Tyr Tyr Gln Ala Ser
 1               5          


<210> 888
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 888
Asp Thr Tyr Tyr Gln Ser Ser
 1               5          


<210> 889
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 889
Asp Thr Tyr Tyr Gln Lys Ser
 1               5          


<210> 890
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 890
Asp Thr Tyr Tyr Gln Arg Ser
 1               5          


<210> 891
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 891
Asp Thr Tyr Tyr Gln His Ser
 1               5          


<210> 892
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 892
Asp Thr Tyr Tyr Gln Pro Ser
 1               5          


<210> 893
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 893
Asp Thr Tyr Tyr Gln Thr Ser
 1               5          


<210> 894
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 894
Asp Thr Tyr Tyr Gln Asp Ser
 1               5          


<210> 895
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 895
Asp Thr Tyr Phe Leu Ala Ser
 1               5          


<210> 896
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 896
Asp Thr Tyr Phe Leu Ser Ser
 1               5          


<210> 897
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 897
Asp Thr Tyr Phe Leu Lys Ser
 1               5          


<210> 898
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 898
Asp Thr Tyr Phe Leu Arg Ser
 1               5          


<210> 899
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 899
Asp Thr Tyr Phe Leu His Ser
 1               5          


<210> 900
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 900
Asp Thr Tyr Phe Leu Pro Ser
 1               5          


<210> 901
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 901
Asp Thr Tyr Phe Leu Thr Ser
 1               5          


<210> 902
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 902
Asp Thr Tyr Phe Leu Asp Ser
 1               5          


<210> 903
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 903
Asp Thr Tyr Phe His Ala Ser
 1               5          


<210> 904
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 904
Asp Thr Tyr Phe His Ser Ser
 1               5          


<210> 905
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 905
Asp Thr Tyr Phe His Lys Ser
 1               5          


<210> 906
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 906
Asp Thr Tyr Phe His Arg Ser
 1               5          


<210> 907
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 907
Asp Thr Tyr Phe His His Ser
 1               5          


<210> 908
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 908
Asp Thr Tyr Phe His Pro Ser
 1               5          


<210> 909
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 909
Asp Thr Tyr Phe His Thr Ser
 1               5          


<210> 910
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 910
Asp Thr Tyr Phe His Asp Ser
 1               5          


<210> 911
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 911
Asp Thr Tyr Phe Gln Ala Ser
 1               5          


<210> 912
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 912
Asp Thr Tyr Phe Gln Ser Ser
 1               5          


<210> 913
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 913
Asp Thr Tyr Phe Gln Lys Ser
 1               5          


<210> 914
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 914
Asp Thr Tyr Phe Gln Arg Ser
 1               5          


<210> 915
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 915
Asp Thr Tyr Phe Gln His Ser
 1               5          


<210> 916
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 916
Asp Thr Tyr Phe Gln Pro Ser
 1               5          


<210> 917
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 917
Asp Thr Tyr Phe Gln Thr Ser
 1               5          


<210> 918
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 918
Asp Thr Tyr Phe Gln Asp Ser
 1               5          


<210> 919
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 919
Asp Thr Tyr Leu Leu Ala Ser
 1               5          


<210> 920
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 920
Asp Thr Tyr Leu Leu Ser Ser
 1               5          


<210> 921
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 921
Asp Thr Tyr Leu Leu Lys Ser
 1               5          


<210> 922
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 922
Asp Thr Tyr Leu Leu Arg Ser
 1               5          


<210> 923
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 923
Asp Thr Tyr Leu Leu His Ser
 1               5          


<210> 924
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 924
Asp Thr Tyr Leu Leu Pro Ser
 1               5          


<210> 925
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 925
Asp Thr Tyr Leu Leu Thr Ser
 1               5          


<210> 926
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 926
Asp Thr Tyr Leu Leu Asp Ser
 1               5          


<210> 927
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 927
Asp Thr Tyr Leu His Ala Ser
 1               5          


<210> 928
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 928
Asp Thr Tyr Leu His Ser Ser
 1               5          


<210> 929
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 929
Asp Thr Tyr Leu His Lys Ser
 1               5          


<210> 930
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 930
Asp Thr Tyr Leu His Arg Ser
 1               5          


<210> 931
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 931
Asp Thr Tyr Leu His His Ser
 1               5          


<210> 932
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 932
Asp Thr Tyr Leu His Pro Ser
 1               5          


<210> 933
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 933
Asp Thr Tyr Leu His Thr Ser
 1               5          


<210> 934
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 934
Asp Thr Tyr Leu His Asp Ser
 1               5          


<210> 935
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 935
Asp Thr Tyr Leu Gln Ala Ser
 1               5          


<210> 936
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 936
Asp Thr Tyr Leu Gln Ser Ser
 1               5          


<210> 937
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 937
Asp Thr Tyr Leu Gln Lys Ser
 1               5          


<210> 938
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 938
Asp Thr Tyr Leu Gln Arg Ser
 1               5          


<210> 939
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 939
Asp Thr Tyr Leu Gln His Ser
 1               5          


<210> 940
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 940
Asp Thr Tyr Leu Gln Pro Ser
 1               5          


<210> 941
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 941
Asp Thr Tyr Leu Gln Thr Ser
 1               5          


<210> 942
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 942
Asp Thr Tyr Leu Gln Asp Ser
 1               5          


<210> 943
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 943
Asp Thr Arg Lys Leu Lys Ser
 1               5          


<210> 944
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 944
Asp Thr Arg Lys Leu Arg Ser
 1               5          


<210> 945
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 945
Asp Thr Arg Lys Leu His Ser
 1               5          


<210> 946
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 946
Asp Thr Arg Lys Leu Thr Ser
 1               5          


<210> 947
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 947
Asp Thr Arg Lys Leu Asp Ser
 1               5          


<210> 948
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 948
Asp Thr Arg Lys His Ala Ser
 1               5          


<210> 949
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 949
Asp Thr Arg Lys His Ser Ser
 1               5          


<210> 950
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 950
Asp Thr Arg Lys His Lys Ser
 1               5          


<210> 951
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 951
Asp Thr Arg Lys His Arg Ser
 1               5          


<210> 952
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 952
Asp Thr Arg Lys His His Ser
 1               5          


<210> 953
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 953
Asp Thr Arg Lys His Pro Ser
 1               5          


<210> 954
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 954
Asp Thr Arg Lys His Thr Ser
 1               5          


<210> 955
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 955
Asp Thr Arg Lys His Asp Ser
 1               5          


<210> 956
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 956
Asp Thr Arg Lys Gln Lys Ser
 1               5          


<210> 957
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 957
Asp Thr Arg Lys Gln Arg Ser
 1               5          


<210> 958
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 958
Asp Thr Arg Lys Gln His Ser
 1               5          


<210> 959
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 959
Asp Thr Arg Lys Gln Pro Ser
 1               5          


<210> 960
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 960
Asp Thr Arg Lys Gln Thr Ser
 1               5          


<210> 961
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 961
Asp Thr Arg Lys Gln Asp Ser
 1               5          


<210> 962
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 962
Asp Thr Arg Gly Leu Ser Ser
 1               5          


<210> 963
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 963
Asp Thr Arg Gly Leu Lys Ser
 1               5          


<210> 964
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 964
Asp Thr Arg Gly Leu Arg Ser
 1               5          


<210> 965
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 965
Asp Thr Arg Gly Leu His Ser
 1               5          


<210> 966
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 966
Asp Thr Arg Gly Leu Thr Ser
 1               5          


<210> 967
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 967
Asp Thr Arg Gly Leu Asp Ser
 1               5          


<210> 968
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 968
Asp Thr Arg Gly His Ala Ser
 1               5          


<210> 969
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 969
Asp Thr Arg Gly His Ser Ser
 1               5          


<210> 970
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 970
Asp Thr Arg Gly His Lys Ser
 1               5          


<210> 971
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 971
Asp Thr Arg Gly His Arg Ser
 1               5          


<210> 972
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 972
Asp Thr Arg Gly His His Ser
 1               5          


<210> 973
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 973
Asp Thr Arg Gly His Pro Ser
 1               5          


<210> 974
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 974
Asp Thr Arg Gly His Thr Ser
 1               5          


<210> 975
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 975
Asp Thr Arg Gly His Asp Ser
 1               5          


<210> 976
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 976
Asp Thr Arg Gly Gln Ala Ser
 1               5          


<210> 977
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 977
Asp Thr Arg Gly Gln Ser Ser
 1               5          


<210> 978
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 978
Asp Thr Arg Gly Gln Lys Ser
 1               5          


<210> 979
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 979
Asp Thr Arg Gly Gln Arg Ser
 1               5          


<210> 980
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 980
Asp Thr Arg Gly Gln His Ser
 1               5          


<210> 981
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 981
Asp Thr Arg Gly Gln Pro Ser
 1               5          


<210> 982
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 982
Asp Thr Arg Gly Gln Thr Ser
 1               5          


<210> 983
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 983
Asp Thr Arg Gly Gln Asp Ser
 1               5          


<210> 984
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 984
Asp Thr Arg Arg Leu Ala Ser
 1               5          


<210> 985
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 985
Asp Thr Arg Arg Leu Ser Ser
 1               5          


<210> 986
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 986
Asp Thr Arg Arg Leu Lys Ser
 1               5          


<210> 987
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 987
Asp Thr Arg Arg Leu Arg Ser
 1               5          


<210> 988
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 988
Asp Thr Arg Arg Leu His Ser
 1               5          


<210> 989
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 989
Asp Thr Arg Arg Leu Pro Ser
 1               5          


<210> 990
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 990
Asp Thr Arg Arg Leu Thr Ser
 1               5          


<210> 991
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 991
Asp Thr Arg Arg Leu Asp Ser
 1               5          


<210> 992
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 992
Asp Thr Arg Arg His Ala Ser
 1               5          


<210> 993
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 993
Asp Thr Arg Arg His Ser Ser
 1               5          


<210> 994
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 994
Asp Thr Arg Arg His Lys Ser
 1               5          


<210> 995
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 995
Asp Thr Arg Arg His Arg Ser
 1               5          


<210> 996
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 996
Asp Thr Arg Arg His His Ser
 1               5          


<210> 997
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 997
Asp Thr Arg Arg His Pro Ser
 1               5          


<210> 998
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 998
Asp Thr Arg Arg His Thr Ser
 1               5          


<210> 999
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 999
Asp Thr Arg Arg His Asp Ser
 1               5          


<210> 1000
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1000
Asp Thr Arg Arg Gln Ala Ser
 1               5          


<210> 1001
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1001
Asp Thr Arg Arg Gln Ser Ser
 1               5          


<210> 1002
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1002
Asp Thr Arg Arg Gln Lys Ser
 1               5          


<210> 1003
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1003
Asp Thr Arg Arg Gln Arg Ser
 1               5          


<210> 1004
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1004
Asp Thr Arg Arg Gln His Ser
 1               5          


<210> 1005
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1005
Asp Thr Arg Arg Gln Pro Ser
 1               5          


<210> 1006
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1006
Asp Thr Arg Arg Gln Thr Ser
 1               5          


<210> 1007
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1007
Asp Thr Arg Arg Gln Asp Ser
 1               5          


<210> 1008
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1008
Asp Thr Arg Tyr Leu Lys Ser
 1               5          


<210> 1009
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1009
Asp Thr Arg Tyr Leu Arg Ser
 1               5          


<210> 1010
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1010
Asp Thr Arg Tyr Leu His Ser
 1               5          


<210> 1011
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1011
Asp Thr Arg Tyr Leu Pro Ser
 1               5          


<210> 1012
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1012
Asp Thr Arg Tyr Leu Thr Ser
 1               5          


<210> 1013
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1013
Asp Thr Arg Tyr Leu Asp Ser
 1               5          


<210> 1014
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1014
Asp Thr Arg Tyr His Ala Ser
 1               5          


<210> 1015
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1015
Asp Thr Arg Tyr His Ser Ser
 1               5          


<210> 1016
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1016
Asp Thr Arg Tyr His Lys Ser
 1               5          


<210> 1017
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1017
Asp Thr Arg Tyr His Arg Ser
 1               5          


<210> 1018
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1018
Asp Thr Arg Tyr His His Ser
 1               5          


<210> 1019
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1019
Asp Thr Arg Tyr His Pro Ser
 1               5          


<210> 1020
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1020
Asp Thr Arg Tyr His Thr Ser
 1               5          


<210> 1021
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1021
Asp Thr Arg Tyr His Asp Ser
 1               5          


<210> 1022
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1022
Asp Thr Arg Tyr Gln Lys Ser
 1               5          


<210> 1023
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1023
Asp Thr Arg Tyr Gln Arg Ser
 1               5          


<210> 1024
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1024
Asp Thr Arg Tyr Gln His Ser
 1               5          


<210> 1025
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1025
Asp Thr Arg Tyr Gln Pro Ser
 1               5          


<210> 1026
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1026
Asp Thr Arg Tyr Gln Thr Ser
 1               5          


<210> 1027
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1027
Asp Thr Arg Tyr Gln Asp Ser
 1               5          


<210> 1028
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1028
Asp Thr Arg Phe Leu Ala Ser
 1               5          


<210> 1029
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1029
Asp Thr Arg Phe Leu Ser Ser
 1               5          


<210> 1030
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1030
Asp Thr Arg Phe Leu Lys Ser
 1               5          


<210> 1031
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1031
Asp Thr Arg Phe Leu Arg Ser
 1               5          


<210> 1032
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1032
Asp Thr Arg Phe Leu His Ser
 1               5          


<210> 1033
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1033
Asp Thr Arg Phe Leu Pro Ser
 1               5          


<210> 1034
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1034
Asp Thr Arg Phe Leu Thr Ser
 1               5          


<210> 1035
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1035
Asp Thr Arg Phe Leu Asp Ser
 1               5          


<210> 1036
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1036
Asp Thr Arg Phe His Ala Ser
 1               5          


<210> 1037
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1037
Asp Thr Arg Phe His Ser Ser
 1               5          


<210> 1038
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1038
Asp Thr Arg Phe His Lys Ser
 1               5          


<210> 1039
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1039
Asp Thr Arg Phe His Arg Ser
 1               5          


<210> 1040
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1040
Asp Thr Arg Phe His His Ser
 1               5          


<210> 1041
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1041
Asp Thr Arg Phe His Pro Ser
 1               5          


<210> 1042
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1042
Asp Thr Arg Phe His Thr Ser
 1               5          


<210> 1043
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1043
Asp Thr Arg Phe His Asp Ser
 1               5          


<210> 1044
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1044
Asp Thr Arg Phe Gln Ala Ser
 1               5          


<210> 1045
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1045
Asp Thr Arg Phe Gln Ser Ser
 1               5          


<210> 1046
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1046
Asp Thr Arg Phe Gln Lys Ser
 1               5          


<210> 1047
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1047
Asp Thr Arg Phe Gln Arg Ser
 1               5          


<210> 1048
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1048
Asp Thr Arg Phe Gln His Ser
 1               5          


<210> 1049
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1049
Asp Thr Arg Phe Gln Pro Ser
 1               5          


<210> 1050
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1050
Asp Thr Arg Phe Gln Thr Ser
 1               5          


<210> 1051
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1051
Asp Thr Arg Phe Gln Asp Ser
 1               5          


<210> 1052
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1052
Asp Thr Arg Leu Leu Ala Ser
 1               5          


<210> 1053
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1053
Asp Thr Arg Leu Leu Ser Ser
 1               5          


<210> 1054
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1054
Asp Thr Arg Leu Leu Lys Ser
 1               5          


<210> 1055
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1055
Asp Thr Arg Leu Leu Arg Ser
 1               5          


<210> 1056
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1056
Asp Thr Arg Leu Leu His Ser
 1               5          


<210> 1057
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1057
Asp Thr Arg Leu Leu Pro Ser
 1               5          


<210> 1058
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1058
Asp Thr Arg Leu Leu Thr Ser
 1               5          


<210> 1059
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1059
Asp Thr Arg Leu Leu Asp Ser
 1               5          


<210> 1060
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1060
Asp Thr Arg Leu His Ala Ser
 1               5          


<210> 1061
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1061
Asp Thr Arg Leu His Ser Ser
 1               5          


<210> 1062
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1062
Asp Thr Arg Leu His Lys Ser
 1               5          


<210> 1063
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1063
Asp Thr Arg Leu His Arg Ser
 1               5          


<210> 1064
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1064
Asp Thr Arg Leu His His Ser
 1               5          


<210> 1065
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1065
Asp Thr Arg Leu His Pro Ser
 1               5          


<210> 1066
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1066
Asp Thr Arg Leu His Thr Ser
 1               5          


<210> 1067
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1067
Asp Thr Arg Leu His Asp Ser
 1               5          


<210> 1068
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1068
Asp Thr Arg Leu Gln Ala Ser
 1               5          


<210> 1069
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1069
Asp Thr Arg Leu Gln Ser Ser
 1               5          


<210> 1070
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1070
Asp Thr Arg Leu Gln Lys Ser
 1               5          


<210> 1071
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1071
Asp Thr Arg Leu Gln Arg Ser
 1               5          


<210> 1072
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1072
Asp Thr Arg Leu Gln His Ser
 1               5          


<210> 1073
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1073
Asp Thr Arg Leu Gln Pro Ser
 1               5          


<210> 1074
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1074
Asp Thr Arg Leu Gln Thr Ser
 1               5          


<210> 1075
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1075
Asp Thr Arg Leu Gln Asp Ser
 1               5          


<210> 1076
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1076
Asp Thr Met Lys Leu Lys Ser
 1               5          


<210> 1077
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1077
Asp Thr Met Lys Leu Arg Ser
 1               5          


<210> 1078
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1078
Asp Thr Met Lys Leu His Ser
 1               5          


<210> 1079
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1079
Asp Thr Met Lys Leu Pro Ser
 1               5          


<210> 1080
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1080
Asp Thr Met Lys Leu Thr Ser
 1               5          


<210> 1081
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1081
Asp Thr Met Lys Leu Asp Ser
 1               5          


<210> 1082
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1082
Asp Thr Met Lys His Ala Ser
 1               5          


<210> 1083
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1083
Asp Thr Met Lys His Ser Ser
 1               5          


<210> 1084
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1084
Asp Thr Met Lys His Lys Ser
 1               5          


<210> 1085
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1085
Asp Thr Met Lys His Arg Ser
 1               5          


<210> 1086
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1086
Asp Thr Met Lys His His Ser
 1               5          


<210> 1087
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1087
Asp Thr Met Lys His Pro Ser
 1               5          


<210> 1088
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1088
Asp Thr Met Lys His Thr Ser
 1               5          


<210> 1089
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1089
Asp Thr Met Lys His Asp Ser
 1               5          


<210> 1090
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1090
Asp Thr Met Lys Gln Lys Ser
 1               5          


<210> 1091
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1091
Asp Thr Met Lys Gln Arg Ser
 1               5          


<210> 1092
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1092
Asp Thr Met Lys Gln His Ser
 1               5          


<210> 1093
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1093
Asp Thr Met Lys Gln Pro Ser
 1               5          


<210> 1094
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1094
Asp Thr Met Lys Gln Thr Ser
 1               5          


<210> 1095
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1095
Asp Thr Met Lys Gln Asp Ser
 1               5          


<210> 1096
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1096
Asp Thr Met Gly Leu Ala Ser
 1               5          


<210> 1097
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1097
Asp Thr Met Gly Leu Ser Ser
 1               5          


<210> 1098
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1098
Asp Thr Met Gly Leu Lys Ser
 1               5          


<210> 1099
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1099
Asp Thr Met Gly Leu Arg Ser
 1               5          


<210> 1100
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1100
Asp Thr Met Gly Leu His Ser
 1               5          


<210> 1101
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1101
Asp Thr Met Gly Leu Pro Ser
 1               5          


<210> 1102
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1102
Asp Thr Met Gly Leu Thr Ser
 1               5          


<210> 1103
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1103
Asp Thr Met Gly Leu Asp Ser
 1               5          


<210> 1104
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1104
Asp Thr Met Gly His Ala Ser
 1               5          


<210> 1105
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1105
Asp Thr Met Gly His Ser Ser
 1               5          


<210> 1106
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1106
Asp Thr Met Gly His Lys Ser
 1               5          


<210> 1107
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1107
Asp Thr Met Gly His Arg Ser
 1               5          


<210> 1108
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1108
Asp Thr Met Gly His His Ser
 1               5          


<210> 1109
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1109
Asp Thr Met Gly His Pro Ser
 1               5          


<210> 1110
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1110
Asp Thr Met Gly His Thr Ser
 1               5          


<210> 1111
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1111
Asp Thr Met Gly His Asp Ser
 1               5          


<210> 1112
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1112
Asp Thr Met Gly Gln Ala Ser
 1               5          


<210> 1113
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1113
Asp Thr Met Gly Gln Ser Ser
 1               5          


<210> 1114
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1114
Asp Thr Met Gly Gln Lys Ser
 1               5          


<210> 1115
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1115
Asp Thr Met Gly Gln Arg Ser
 1               5          


<210> 1116
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1116
Asp Thr Met Gly Gln His Ser
 1               5          


<210> 1117
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1117
Asp Thr Met Gly Gln Pro Ser
 1               5          


<210> 1118
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1118
Asp Thr Met Gly Gln Thr Ser
 1               5          


<210> 1119
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1119
Asp Thr Met Gly Gln Asp Ser
 1               5          


<210> 1120
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1120
Asp Thr Met Arg Leu Ser Ser
 1               5          


<210> 1121
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1121
Asp Thr Met Arg Leu Lys Ser
 1               5          


<210> 1122
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1122
Asp Thr Met Arg Leu Arg Ser
 1               5          


<210> 1123
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1123
Asp Thr Met Arg Leu His Ser
 1               5          


<210> 1124
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1124
Asp Thr Met Arg Leu Pro Ser
 1               5          


<210> 1125
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1125
Asp Thr Met Arg Leu Thr Ser
 1               5          


<210> 1126
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1126
Asp Thr Met Arg Leu Asp Ser
 1               5          


<210> 1127
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1127
Asp Thr Met Arg His Ala Ser
 1               5          


<210> 1128
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1128
Asp Thr Met Arg His Ser Ser
 1               5          


<210> 1129
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1129
Asp Thr Met Arg His Lys Ser
 1               5          


<210> 1130
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1130
Asp Thr Met Arg His Arg Ser
 1               5          


<210> 1131
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1131
Asp Thr Met Arg His His Ser
 1               5          


<210> 1132
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1132
Asp Thr Met Arg His Pro Ser
 1               5          


<210> 1133
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1133
Asp Thr Met Arg His Thr Ser
 1               5          


<210> 1134
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1134
Asp Thr Met Arg His Asp Ser
 1               5          


<210> 1135
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1135
Asp Thr Met Arg Gln Ala Ser
 1               5          


<210> 1136
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1136
Asp Thr Met Arg Gln Ser Ser
 1               5          


<210> 1137
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1137
Asp Thr Met Arg Gln Lys Ser
 1               5          


<210> 1138
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1138
Asp Thr Met Arg Gln Arg Ser
 1               5          


<210> 1139
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1139
Asp Thr Met Arg Gln His Ser
 1               5          


<210> 1140
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1140
Asp Thr Met Arg Gln Pro Ser
 1               5          


<210> 1141
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1141
Asp Thr Met Arg Gln Thr Ser
 1               5          


<210> 1142
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1142
Asp Thr Met Arg Gln Asp Ser
 1               5          


<210> 1143
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1143
Asp Thr Met Tyr Leu Lys Ser
 1               5          


<210> 1144
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1144
Asp Thr Met Tyr Leu Arg Ser
 1               5          


<210> 1145
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1145
Asp Thr Met Tyr Leu His Ser
 1               5          


<210> 1146
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1146
Asp Thr Met Tyr Leu Pro Ser
 1               5          


<210> 1147
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1147
Asp Thr Met Tyr Leu Thr Ser
 1               5          


<210> 1148
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1148
Asp Thr Met Tyr Leu Asp Ser
 1               5          


<210> 1149
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1149
Asp Thr Met Tyr His Ala Ser
 1               5          


<210> 1150
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1150
Asp Thr Met Tyr His Ser Ser
 1               5          


<210> 1151
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1151
Asp Thr Met Tyr His Lys Ser
 1               5          


<210> 1152
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1152
Asp Thr Met Tyr His Arg Ser
 1               5          


<210> 1153
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1153
Asp Thr Met Tyr His His Ser
 1               5          


<210> 1154
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1154
Asp Thr Met Tyr His Pro Ser
 1               5          


<210> 1155
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1155
Asp Thr Met Tyr His Thr Ser
 1               5          


<210> 1156
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1156
Asp Thr Met Tyr His Asp Ser
 1               5          


<210> 1157
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1157
Asp Thr Met Tyr Gln Lys Ser
 1               5          


<210> 1158
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1158
Asp Thr Met Tyr Gln Arg Ser
 1               5          


<210> 1159
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1159
Asp Thr Met Tyr Gln His Ser
 1               5          


<210> 1160
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1160
Asp Thr Met Tyr Gln Pro Ser
 1               5          


<210> 1161
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1161
Asp Thr Met Tyr Gln Thr Ser
 1               5          


<210> 1162
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1162
Asp Thr Met Tyr Gln Asp Ser
 1               5          


<210> 1163
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1163
Asp Thr Met Phe Leu Ala Ser
 1               5          


<210> 1164
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1164
Asp Thr Met Phe Leu Ser Ser
 1               5          


<210> 1165
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1165
Asp Thr Met Phe Leu Lys Ser
 1               5          


<210> 1166
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1166
Asp Thr Met Phe Leu Arg Ser
 1               5          


<210> 1167
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1167
Asp Thr Met Phe Leu His Ser
 1               5          


<210> 1168
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1168
Asp Thr Met Phe Leu Pro Ser
 1               5          


<210> 1169
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1169
Asp Thr Met Phe Leu Thr Ser
 1               5          


<210> 1170
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1170
Asp Thr Met Phe Leu Asp Ser
 1               5          


<210> 1171
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1171
Asp Thr Met Phe His Ala Ser
 1               5          


<210> 1172
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1172
Asp Thr Met Phe His Ser Ser
 1               5          


<210> 1173
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1173
Asp Thr Met Phe His Lys Ser
 1               5          


<210> 1174
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1174
Asp Thr Met Phe His Arg Ser
 1               5          


<210> 1175
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1175
Asp Thr Met Phe His His Ser
 1               5          


<210> 1176
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1176
Asp Thr Met Phe His Pro Ser
 1               5          


<210> 1177
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1177
Asp Thr Met Phe His Thr Ser
 1               5          


<210> 1178
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1178
Asp Thr Met Phe His Asp Ser
 1               5          


<210> 1179
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1179
Asp Thr Met Phe Gln Ala Ser
 1               5          


<210> 1180
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1180
Asp Thr Met Phe Gln Ser Ser
 1               5          


<210> 1181
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1181
Asp Thr Met Phe Gln Lys Ser
 1               5          


<210> 1182
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1182
Asp Thr Met Phe Gln Arg Ser
 1               5          


<210> 1183
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1183
Asp Thr Met Phe Gln His Ser
 1               5          


<210> 1184
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1184
Asp Thr Met Phe Gln Pro Ser
 1               5          


<210> 1185
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1185
Asp Thr Met Phe Gln Thr Ser
 1               5          


<210> 1186
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1186
Asp Thr Met Phe Gln Asp Ser
 1               5          


<210> 1187
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1187
Asp Thr Met Leu Leu Ala Ser
 1               5          


<210> 1188
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1188
Asp Thr Met Leu Leu Ser Ser
 1               5          


<210> 1189
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1189
Asp Thr Met Leu Leu Lys Ser
 1               5          


<210> 1190
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1190
Asp Thr Met Leu Leu Arg Ser
 1               5          


<210> 1191
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1191
Asp Thr Met Leu Leu His Ser
 1               5          


<210> 1192
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1192
Asp Thr Met Leu Leu Pro Ser
 1               5          


<210> 1193
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1193
Asp Thr Met Leu Leu Thr Ser
 1               5          


<210> 1194
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1194
Asp Thr Met Leu Leu Asp Ser
 1               5          


<210> 1195
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1195
Asp Thr Met Leu His Ala Ser
 1               5          


<210> 1196
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1196
Asp Thr Met Leu His Ser Ser
 1               5          


<210> 1197
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1197
Asp Thr Met Leu His Lys Ser
 1               5          


<210> 1198
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1198
Asp Thr Met Leu His Arg Ser
 1               5          


<210> 1199
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1199
Asp Thr Met Leu His His Ser
 1               5          


<210> 1200
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1200
Asp Thr Met Leu His Pro Ser
 1               5          


<210> 1201
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1201
Asp Thr Met Leu His Thr Ser
 1               5          


<210> 1202
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1202
Asp Thr Met Leu His Asp Ser
 1               5          


<210> 1203
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1203
Asp Thr Met Leu Gln Ala Ser
 1               5          


<210> 1204
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1204
Asp Thr Met Leu Gln Ser Ser
 1               5          


<210> 1205
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1205
Asp Thr Met Leu Gln Lys Ser
 1               5          


<210> 1206
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1206
Asp Thr Met Leu Gln Arg Ser
 1               5          


<210> 1207
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1207
Asp Thr Met Leu Gln His Ser
 1               5          


<210> 1208
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1208
Asp Thr Met Leu Gln Pro Ser
 1               5          


<210> 1209
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1209
Asp Thr Met Leu Gln Thr Ser
 1               5          


<210> 1210
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1210
Asp Thr Met Leu Gln Asp Ser
 1               5          


<210> 1211
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1211
Asp Thr Lys Lys Leu Ala Ser
 1               5          


<210> 1212
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1212
Asp Thr Lys Lys Leu Ser Ser
 1               5          


<210> 1213
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1213
Asp Thr Lys Lys Leu Lys Ser
 1               5          


<210> 1214
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1214
Asp Thr Lys Lys Leu Arg Ser
 1               5          


<210> 1215
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1215
Asp Thr Lys Lys Leu His Ser
 1               5          


<210> 1216
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1216
Asp Thr Lys Lys Leu Pro Ser
 1               5          


<210> 1217
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1217
Asp Thr Lys Lys Leu Thr Ser
 1               5          


<210> 1218
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1218
Asp Thr Lys Lys Leu Asp Ser
 1               5          


<210> 1219
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1219
Asp Thr Lys Lys His Ala Ser
 1               5          


<210> 1220
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1220
Asp Thr Lys Lys His Ser Ser
 1               5          


<210> 1221
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1221
Asp Thr Lys Lys His Lys Ser
 1               5          


<210> 1222
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1222
Asp Thr Lys Lys His Arg Ser
 1               5          


<210> 1223
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1223
Asp Thr Lys Lys His His Ser
 1               5          


<210> 1224
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1224
Asp Thr Lys Lys His Pro Ser
 1               5          


<210> 1225
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1225
Asp Thr Lys Lys His Thr Ser
 1               5          


<210> 1226
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1226
Asp Thr Lys Lys His Asp Ser
 1               5          


<210> 1227
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1227
Asp Thr Lys Lys Gln Ala Ser
 1               5          


<210> 1228
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1228
Asp Thr Lys Lys Gln Ser Ser
 1               5          


<210> 1229
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1229
Asp Thr Lys Lys Gln Lys Ser
 1               5          


<210> 1230
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1230
Asp Thr Lys Lys Gln Arg Ser
 1               5          


<210> 1231
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1231
Asp Thr Lys Lys Gln His Ser
 1               5          


<210> 1232
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1232
Asp Thr Lys Lys Gln Pro Ser
 1               5          


<210> 1233
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1233
Asp Thr Lys Lys Gln Thr Ser
 1               5          


<210> 1234
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1234
Asp Thr Lys Lys Gln Asp Ser
 1               5          


<210> 1235
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1235
Asp Thr Lys Gly Leu Ala Ser
 1               5          


<210> 1236
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1236
Asp Thr Lys Gly Leu Ser Ser
 1               5          


<210> 1237
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1237
Asp Thr Lys Gly Leu Lys Ser
 1               5          


<210> 1238
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1238
Asp Thr Lys Gly Leu Arg Ser
 1               5          


<210> 1239
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1239
Asp Thr Lys Gly Leu His Ser
 1               5          


<210> 1240
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1240
Asp Thr Lys Gly Leu Pro Ser
 1               5          


<210> 1241
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1241
Asp Thr Lys Gly Leu Thr Ser
 1               5          


<210> 1242
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1242
Asp Thr Lys Gly Leu Asp Ser
 1               5          


<210> 1243
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1243
Asp Thr Lys Gly His Ala Ser
 1               5          


<210> 1244
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1244
Asp Thr Lys Gly His Ser Ser
 1               5          


<210> 1245
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1245
Asp Thr Lys Gly His Lys Ser
 1               5          


<210> 1246
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1246
Asp Thr Lys Gly His Arg Ser
 1               5          


<210> 1247
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1247
Asp Thr Lys Gly His His Ser
 1               5          


<210> 1248
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1248
Asp Thr Lys Gly His Pro Ser
 1               5          


<210> 1249
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1249
Asp Thr Lys Gly His Thr Ser
 1               5          


<210> 1250
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1250
Asp Thr Lys Gly His Asp Ser
 1               5          


<210> 1251
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1251
Asp Thr Lys Gly Gln Ala Ser
 1               5          


<210> 1252
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1252
Asp Thr Lys Gly Gln Ser Ser
 1               5          


<210> 1253
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1253
Asp Thr Lys Gly Gln Lys Ser
 1               5          


<210> 1254
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1254
Asp Thr Lys Gly Gln Arg Ser
 1               5          


<210> 1255
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1255
Asp Thr Lys Gly Gln His Ser
 1               5          


<210> 1256
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1256
Asp Thr Lys Gly Gln Pro Ser
 1               5          


<210> 1257
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1257
Asp Thr Lys Gly Gln Thr Ser
 1               5          


<210> 1258
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1258
Asp Thr Lys Gly Gln Asp Ser
 1               5          


<210> 1259
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1259
Asp Thr Lys Arg Leu Ala Ser
 1               5          


<210> 1260
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1260
Asp Thr Lys Arg Leu Ser Ser
 1               5          


<210> 1261
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1261
Asp Thr Lys Arg Leu Lys Ser
 1               5          


<210> 1262
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1262
Asp Thr Lys Arg Leu Arg Ser
 1               5          


<210> 1263
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1263
Asp Thr Lys Arg Leu His Ser
 1               5          


<210> 1264
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1264
Asp Thr Lys Arg Leu Pro Ser
 1               5          


<210> 1265
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1265
Asp Thr Lys Arg Leu Thr Ser
 1               5          


<210> 1266
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1266
Asp Thr Lys Arg Leu Asp Ser
 1               5          


<210> 1267
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1267
Asp Thr Lys Arg His Ala Ser
 1               5          


<210> 1268
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1268
Asp Thr Lys Arg His Ser Ser
 1               5          


<210> 1269
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1269
Asp Thr Lys Arg His Lys Ser
 1               5          


<210> 1270
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1270
Asp Thr Lys Arg His Arg Ser
 1               5          


<210> 1271
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1271
Asp Thr Lys Arg His His Ser
 1               5          


<210> 1272
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1272
Asp Thr Lys Arg His Pro Ser
 1               5          


<210> 1273
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1273
Asp Thr Lys Arg His Thr Ser
 1               5          


<210> 1274
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1274
Asp Thr Lys Arg His Asp Ser
 1               5          


<210> 1275
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1275
Asp Thr Lys Arg Gln Ala Ser
 1               5          


<210> 1276
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1276
Asp Thr Lys Arg Gln Ser Ser
 1               5          


<210> 1277
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1277
Asp Thr Lys Arg Gln Lys Ser
 1               5          


<210> 1278
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1278
Asp Thr Lys Arg Gln Arg Ser
 1               5          


<210> 1279
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1279
Asp Thr Lys Arg Gln His Ser
 1               5          


<210> 1280
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1280
Asp Thr Lys Arg Gln Pro Ser
 1               5          


<210> 1281
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1281
Asp Thr Lys Arg Gln Thr Ser
 1               5          


<210> 1282
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1282
Asp Thr Lys Arg Gln Asp Ser
 1               5          


<210> 1283
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1283
Asp Thr Lys Tyr Leu Ala Ser
 1               5          


<210> 1284
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1284
Asp Thr Lys Tyr Leu Ser Ser
 1               5          


<210> 1285
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1285
Asp Thr Lys Tyr Leu Lys Ser
 1               5          


<210> 1286
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1286
Asp Thr Lys Tyr Leu Arg Ser
 1               5          


<210> 1287
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1287
Asp Thr Lys Tyr Leu His Ser
 1               5          


<210> 1288
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1288
Asp Thr Lys Tyr Leu Pro Ser
 1               5          


<210> 1289
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1289
Asp Thr Lys Tyr Leu Thr Ser
 1               5          


<210> 1290
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1290
Asp Thr Lys Tyr Leu Asp Ser
 1               5          


<210> 1291
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1291
Asp Thr Lys Tyr His Ala Ser
 1               5          


<210> 1292
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1292
Asp Thr Lys Tyr His Ser Ser
 1               5          


<210> 1293
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1293
Asp Thr Lys Tyr His Lys Ser
 1               5          


<210> 1294
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1294
Asp Thr Lys Tyr His Arg Ser
 1               5          


<210> 1295
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1295
Asp Thr Lys Tyr His His Ser
 1               5          


<210> 1296
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1296
Asp Thr Lys Tyr His Pro Ser
 1               5          


<210> 1297
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1297
Asp Thr Lys Tyr His Thr Ser
 1               5          


<210> 1298
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1298
Asp Thr Lys Tyr His Asp Ser
 1               5          


<210> 1299
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1299
Asp Thr Lys Tyr Gln Ala Ser
 1               5          


<210> 1300
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1300
Asp Thr Lys Tyr Gln Ser Ser
 1               5          


<210> 1301
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1301
Asp Thr Lys Tyr Gln Lys Ser
 1               5          


<210> 1302
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1302
Asp Thr Lys Tyr Gln Arg Ser
 1               5          


<210> 1303
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1303
Asp Thr Lys Tyr Gln His Ser
 1               5          


<210> 1304
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1304
Asp Thr Lys Tyr Gln Pro Ser
 1               5          


<210> 1305
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1305
Asp Thr Lys Tyr Gln Thr Ser
 1               5          


<210> 1306
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1306
Asp Thr Lys Tyr Gln Asp Ser
 1               5          


<210> 1307
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1307
Asp Thr Lys Phe Leu Ala Ser
 1               5          


<210> 1308
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1308
Asp Thr Lys Phe Leu Ser Ser
 1               5          


<210> 1309
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1309
Asp Thr Lys Phe Leu Lys Ser
 1               5          


<210> 1310
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1310
Asp Thr Lys Phe Leu Arg Ser
 1               5          


<210> 1311
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1311
Asp Thr Lys Phe Leu His Ser
 1               5          


<210> 1312
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1312
Asp Thr Lys Phe Leu Pro Ser
 1               5          


<210> 1313
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1313
Asp Thr Lys Phe Leu Thr Ser
 1               5          


<210> 1314
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1314
Asp Thr Lys Phe Leu Asp Ser
 1               5          


<210> 1315
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1315
Asp Thr Lys Phe His Ala Ser
 1               5          


<210> 1316
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1316
Asp Thr Lys Phe His Ser Ser
 1               5          


<210> 1317
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1317
Asp Thr Lys Phe His Lys Ser
 1               5          


<210> 1318
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1318
Asp Thr Lys Phe His Arg Ser
 1               5          


<210> 1319
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1319
Asp Thr Lys Phe His His Ser
 1               5          


<210> 1320
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1320
Asp Thr Lys Phe His Pro Ser
 1               5          


<210> 1321
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1321
Asp Thr Lys Phe His Thr Ser
 1               5          


<210> 1322
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1322
Asp Thr Lys Phe His Asp Ser
 1               5          


<210> 1323
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1323
Asp Thr Lys Phe Gln Ala Ser
 1               5          


<210> 1324
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1324
Asp Thr Lys Phe Gln Ser Ser
 1               5          


<210> 1325
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1325
Asp Thr Lys Phe Gln Lys Ser
 1               5          


<210> 1326
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1326
Asp Thr Lys Phe Gln Arg Ser
 1               5          


<210> 1327
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1327
Asp Thr Lys Phe Gln His Ser
 1               5          


<210> 1328
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1328
Asp Thr Lys Phe Gln Pro Ser
 1               5          


<210> 1329
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1329
Asp Thr Lys Phe Gln Thr Ser
 1               5          


<210> 1330
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1330
Asp Thr Lys Phe Gln Asp Ser
 1               5          


<210> 1331
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1331
Asp Thr Lys Leu Leu Ala Ser
 1               5          


<210> 1332
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1332
Asp Thr Lys Leu Leu Ser Ser
 1               5          


<210> 1333
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1333
Asp Thr Lys Leu Leu Lys Ser
 1               5          


<210> 1334
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1334
Asp Thr Lys Leu Leu Arg Ser
 1               5          


<210> 1335
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1335
Asp Thr Lys Leu Leu His Ser
 1               5          


<210> 1336
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1336
Asp Thr Lys Leu Leu Pro Ser
 1               5          


<210> 1337
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1337
Asp Thr Lys Leu Leu Thr Ser
 1               5          


<210> 1338
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1338
Asp Thr Lys Leu Leu Asp Ser
 1               5          


<210> 1339
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1339
Asp Thr Lys Leu His Ala Ser
 1               5          


<210> 1340
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1340
Asp Thr Lys Leu His Ser Ser
 1               5          


<210> 1341
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1341
Asp Thr Lys Leu His Lys Ser
 1               5          


<210> 1342
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1342
Asp Thr Lys Leu His Arg Ser
 1               5          


<210> 1343
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1343
Asp Thr Lys Leu His His Ser
 1               5          


<210> 1344
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1344
Asp Thr Lys Leu His Pro Ser
 1               5          


<210> 1345
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1345
Asp Thr Lys Leu His Thr Ser
 1               5          


<210> 1346
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1346
Asp Thr Lys Leu His Asp Ser
 1               5          


<210> 1347
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1347
Asp Thr Lys Leu Gln Ala Ser
 1               5          


<210> 1348
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1348
Asp Thr Lys Leu Gln Ser Ser
 1               5          


<210> 1349
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1349
Asp Thr Lys Leu Gln Lys Ser
 1               5          


<210> 1350
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1350
Asp Thr Lys Leu Gln Arg Ser
 1               5          


<210> 1351
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1351
Asp Thr Lys Leu Gln His Ser
 1               5          


<210> 1352
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1352
Asp Thr Lys Leu Gln Pro Ser
 1               5          


<210> 1353
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1353
Asp Thr Lys Leu Gln Thr Ser
 1               5          


<210> 1354
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1354
Asp Thr Lys Leu Gln Asp Ser
 1               5          


<210> 1355
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1355
Asp Thr Leu Lys Leu Ser Ser
 1               5          


<210> 1356
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1356
Asp Thr Leu Lys Leu Lys Ser
 1               5          


<210> 1357
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1357
Asp Thr Leu Lys Leu Arg Ser
 1               5          


<210> 1358
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1358
Asp Thr Leu Lys Leu His Ser
 1               5          


<210> 1359
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1359
Asp Thr Leu Lys Leu Pro Ser
 1               5          


<210> 1360
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1360
Asp Thr Leu Lys Leu Thr Ser
 1               5          


<210> 1361
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1361
Asp Thr Leu Lys His Ala Ser
 1               5          


<210> 1362
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1362
Asp Thr Leu Lys His Ser Ser
 1               5          


<210> 1363
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1363
Asp Thr Leu Lys His Lys Ser
 1               5          


<210> 1364
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1364
Asp Thr Leu Lys His Arg Ser
 1               5          


<210> 1365
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1365
Asp Thr Leu Lys His His Ser
 1               5          


<210> 1366
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1366
Asp Thr Leu Lys His Pro Ser
 1               5          


<210> 1367
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1367
Asp Thr Leu Lys His Thr Ser
 1               5          


<210> 1368
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1368
Asp Thr Leu Lys His Asp Ser
 1               5          


<210> 1369
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1369
Asp Thr Leu Lys Gln Ala Ser
 1               5          


<210> 1370
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1370
Asp Thr Leu Lys Gln Ser Ser
 1               5          


<210> 1371
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1371
Asp Thr Leu Lys Gln Lys Ser
 1               5          


<210> 1372
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1372
Asp Thr Leu Lys Gln Arg Ser
 1               5          


<210> 1373
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1373
Asp Thr Leu Lys Gln His Ser
 1               5          


<210> 1374
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1374
Asp Thr Leu Lys Gln Pro Ser
 1               5          


<210> 1375
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1375
Asp Thr Leu Lys Gln Thr Ser
 1               5          


<210> 1376
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1376
Asp Thr Leu Lys Gln Asp Ser
 1               5          


<210> 1377
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1377
Asp Thr Leu Gly Leu Ala Ser
 1               5          


<210> 1378
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1378
Asp Thr Leu Gly Leu Ser Ser
 1               5          


<210> 1379
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1379
Asp Thr Leu Gly Leu Lys Ser
 1               5          


<210> 1380
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1380
Asp Thr Leu Gly Leu Arg Ser
 1               5          


<210> 1381
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1381
Asp Thr Leu Gly Leu His Ser
 1               5          


<210> 1382
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1382
Asp Thr Leu Gly Leu Pro Ser
 1               5          


<210> 1383
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1383
Asp Thr Leu Gly Leu Thr Ser
 1               5          


<210> 1384
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1384
Asp Thr Leu Gly Leu Asp Ser
 1               5          


<210> 1385
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1385
Asp Thr Leu Gly His Ala Ser
 1               5          


<210> 1386
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1386
Asp Thr Leu Gly His Ser Ser
 1               5          


<210> 1387
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1387
Asp Thr Leu Gly His Lys Ser
 1               5          


<210> 1388
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1388
Asp Thr Leu Gly His Arg Ser
 1               5          


<210> 1389
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1389
Asp Thr Leu Gly His His Ser
 1               5          


<210> 1390
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1390
Asp Thr Leu Gly His Pro Ser
 1               5          


<210> 1391
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1391
Asp Thr Leu Gly His Thr Ser
 1               5          


<210> 1392
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1392
Asp Thr Leu Gly His Asp Ser
 1               5          


<210> 1393
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1393
Asp Thr Leu Gly Gln Ala Ser
 1               5          


<210> 1394
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1394
Asp Thr Leu Gly Gln Ser Ser
 1               5          


<210> 1395
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1395
Asp Thr Leu Gly Gln Lys Ser
 1               5          


<210> 1396
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1396
Asp Thr Leu Gly Gln Arg Ser
 1               5          


<210> 1397
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1397
Asp Thr Leu Gly Gln His Ser
 1               5          


<210> 1398
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1398
Asp Thr Leu Gly Gln Pro Ser
 1               5          


<210> 1399
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1399
Asp Thr Leu Gly Gln Thr Ser
 1               5          


<210> 1400
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1400
Asp Thr Leu Gly Gln Asp Ser
 1               5          


<210> 1401
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1401
Asp Thr Leu Arg Leu Ala Ser
 1               5          


<210> 1402
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1402
Asp Thr Leu Arg Leu Ser Ser
 1               5          


<210> 1403
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1403
Asp Thr Leu Arg Leu Lys Ser
 1               5          


<210> 1404
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1404
Asp Thr Leu Arg Leu Arg Ser
 1               5          


<210> 1405
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1405
Asp Thr Leu Arg Leu His Ser
 1               5          


<210> 1406
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1406
Asp Thr Leu Arg Leu Pro Ser
 1               5          


<210> 1407
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1407
Asp Thr Leu Arg Leu Thr Ser
 1               5          


<210> 1408
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1408
Asp Thr Leu Arg Leu Asp Ser
 1               5          


<210> 1409
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1409
Asp Thr Leu Arg His Ala Ser
 1               5          


<210> 1410
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1410
Asp Thr Leu Arg His Ser Ser
 1               5          


<210> 1411
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1411
Asp Thr Leu Arg His Lys Ser
 1               5          


<210> 1412
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1412
Asp Thr Leu Arg His Arg Ser
 1               5          


<210> 1413
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1413
Asp Thr Leu Arg His His Ser
 1               5          


<210> 1414
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1414
Asp Thr Leu Arg His Pro Ser
 1               5          


<210> 1415
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1415
Asp Thr Leu Arg His Thr Ser
 1               5          


<210> 1416
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1416
Asp Thr Leu Arg His Asp Ser
 1               5          


<210> 1417
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1417
Asp Thr Leu Arg Gln Ala Ser
 1               5          


<210> 1418
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1418
Asp Thr Leu Arg Gln Ser Ser
 1               5          


<210> 1419
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1419
Asp Thr Leu Arg Gln Lys Ser
 1               5          


<210> 1420
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1420
Asp Thr Leu Arg Gln Arg Ser
 1               5          


<210> 1421
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1421
Asp Thr Leu Arg Gln His Ser
 1               5          


<210> 1422
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1422
Asp Thr Leu Arg Gln Pro Ser
 1               5          


<210> 1423
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1423
Asp Thr Leu Arg Gln Thr Ser
 1               5          


<210> 1424
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1424
Asp Thr Leu Arg Gln Asp Ser
 1               5          


<210> 1425
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1425
Asp Thr Leu Tyr Leu Ala Ser
 1               5          


<210> 1426
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1426
Asp Thr Leu Tyr Leu Ser Ser
 1               5          


<210> 1427
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1427
Asp Thr Leu Tyr Leu Lys Ser
 1               5          


<210> 1428
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1428
Asp Thr Leu Tyr Leu Arg Ser
 1               5          


<210> 1429
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1429
Asp Thr Leu Tyr Leu His Ser
 1               5          


<210> 1430
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1430
Asp Thr Leu Tyr Leu Pro Ser
 1               5          


<210> 1431
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1431
Asp Thr Leu Tyr Leu Thr Ser
 1               5          


<210> 1432
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1432
Asp Thr Leu Tyr Leu Asp Ser
 1               5          


<210> 1433
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1433
Asp Thr Leu Tyr His Ala Ser
 1               5          


<210> 1434
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1434
Asp Thr Leu Tyr His Ser Ser
 1               5          


<210> 1435
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1435
Asp Thr Leu Tyr His Lys Ser
 1               5          


<210> 1436
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1436
Asp Thr Leu Tyr His Arg Ser
 1               5          


<210> 1437
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1437
Asp Thr Leu Tyr His His Ser
 1               5          


<210> 1438
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1438
Asp Thr Leu Tyr His Pro Ser
 1               5          


<210> 1439
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1439
Asp Thr Leu Tyr His Thr Ser
 1               5          


<210> 1440
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1440
Asp Thr Leu Tyr His Asp Ser
 1               5          


<210> 1441
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1441
Asp Thr Leu Tyr Gln Ala Ser
 1               5          


<210> 1442
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1442
Asp Thr Leu Tyr Gln Ser Ser
 1               5          


<210> 1443
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1443
Asp Thr Leu Tyr Gln Lys Ser
 1               5          


<210> 1444
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1444
Asp Thr Leu Tyr Gln Arg Ser
 1               5          


<210> 1445
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1445
Asp Thr Leu Tyr Gln His Ser
 1               5          


<210> 1446
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1446
Asp Thr Leu Tyr Gln Pro Ser
 1               5          


<210> 1447
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1447
Asp Thr Leu Tyr Gln Thr Ser
 1               5          


<210> 1448
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1448
Asp Thr Leu Tyr Gln Asp Ser
 1               5          


<210> 1449
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1449
Asp Thr Leu Phe Leu Ala Ser
 1               5          


<210> 1450
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1450
Asp Thr Leu Phe Leu Ser Ser
 1               5          


<210> 1451
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1451
Asp Thr Leu Phe Leu Lys Ser
 1               5          


<210> 1452
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1452
Asp Thr Leu Phe Leu Arg Ser
 1               5          


<210> 1453
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1453
Asp Thr Leu Phe Leu His Ser
 1               5          


<210> 1454
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1454
Asp Thr Leu Phe Leu Pro Ser
 1               5          


<210> 1455
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1455
Asp Thr Leu Phe Leu Thr Ser
 1               5          


<210> 1456
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1456
Asp Thr Leu Phe Leu Asp Ser
 1               5          


<210> 1457
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1457
Asp Thr Leu Phe His Ala Ser
 1               5          


<210> 1458
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1458
Asp Thr Leu Phe His Ser Ser
 1               5          


<210> 1459
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1459
Asp Thr Leu Phe His Lys Ser
 1               5          


<210> 1460
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1460
Asp Thr Leu Phe His Arg Ser
 1               5          


<210> 1461
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1461
Asp Thr Leu Phe His His Ser
 1               5          


<210> 1462
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1462
Asp Thr Leu Phe His Pro Ser
 1               5          


<210> 1463
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1463
Asp Thr Leu Phe His Thr Ser
 1               5          


<210> 1464
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1464
Asp Thr Leu Phe His Asp Ser
 1               5          


<210> 1465
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1465
Asp Thr Leu Phe Gln Ala Ser
 1               5          


<210> 1466
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1466
Asp Thr Leu Phe Gln Ser Ser
 1               5          


<210> 1467
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1467
Asp Thr Leu Phe Gln Lys Ser
 1               5          


<210> 1468
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1468
Asp Thr Leu Phe Gln Arg Ser
 1               5          


<210> 1469
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1469
Asp Thr Leu Phe Gln His Ser
 1               5          


<210> 1470
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1470
Asp Thr Leu Phe Gln Pro Ser
 1               5          


<210> 1471
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1471
Asp Thr Leu Phe Gln Thr Ser
 1               5          


<210> 1472
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1472
Asp Thr Leu Phe Gln Asp Ser
 1               5          


<210> 1473
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1473
Asp Thr Leu Leu Leu Ser Ser
 1               5          


<210> 1474
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1474
Asp Thr Leu Leu Leu Lys Ser
 1               5          


<210> 1475
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1475
Asp Thr Leu Leu Leu Arg Ser
 1               5          


<210> 1476
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1476
Asp Thr Leu Leu Leu His Ser
 1               5          


<210> 1477
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1477
Asp Thr Leu Leu Leu Pro Ser
 1               5          


<210> 1478
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1478
Asp Thr Leu Leu Leu Thr Ser
 1               5          


<210> 1479
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1479
Asp Thr Leu Leu His Ala Ser
 1               5          


<210> 1480
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1480
Asp Thr Leu Leu His Ser Ser
 1               5          


<210> 1481
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1481
Asp Thr Leu Leu His Lys Ser
 1               5          


<210> 1482
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1482
Asp Thr Leu Leu His Arg Ser
 1               5          


<210> 1483
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1483
Asp Thr Leu Leu His His Ser
 1               5          


<210> 1484
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1484
Asp Thr Leu Leu His Pro Ser
 1               5          


<210> 1485
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1485
Asp Thr Leu Leu His Thr Ser
 1               5          


<210> 1486
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1486
Asp Thr Leu Leu His Asp Ser
 1               5          


<210> 1487
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1487
Asp Thr Leu Leu Gln Ala Ser
 1               5          


<210> 1488
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1488
Asp Thr Leu Leu Gln Ser Ser
 1               5          


<210> 1489
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1489
Asp Thr Leu Leu Gln Lys Ser
 1               5          


<210> 1490
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1490
Asp Thr Leu Leu Gln Arg Ser
 1               5          


<210> 1491
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1491
Asp Thr Leu Leu Gln His Ser
 1               5          


<210> 1492
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1492
Asp Thr Leu Leu Gln Pro Ser
 1               5          


<210> 1493
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1493
Asp Thr Leu Leu Gln Thr Ser
 1               5          


<210> 1494
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1494
Asp Thr Leu Leu Gln Asp Ser
 1               5          

<210> 1495
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1495
Phe Gln Gly Ser Tyr Tyr Pro Phe Thr
 1               5                  


<210> 1496
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence derived from Murine monoclonal
      antibody and further modified by amino acid
      substitutions

<400> 1496
Phe Gln Gly Ser Trp Tyr Pro Phe Thr
 1               5                  
